Actively Recruiting
Impact of Neuromuscular Stimulation and High Protein Nutritional Supplementation on Long-term Recovery After Aneurysmal Subarachnoid Hemorrhage
Led by University of Maryland, Baltimore · Updated on 2026-05-19
30
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether early neuromuscular electrical stimulation (NMES) combined with high protein supplementation (HPRO) can improve muscle mass, metabolic, and inflammatory markers in adults who have experienced aneurysmal subarachnoid hemorrhage (SAH). This study compares patients receiving NMES and HPRO against those receiving standard nutritional and mobilization care. It aims to understand how these interventions may reduce muscle wasting and improve recovery by addressing inflammation and energy balance after SAH. Participants are assigned to one of four groups: standard care, NMES only, HPRO only, or both NMES and HPRO. NMES involves two 30-minute sessions daily, while HPRO is given three times daily, including immediately after NMES and at night. All patients receive standard mobilization and nutrition support throughout the study period. Participants will be closely monitored over a 14-day period with muscle thickness of the quadriceps measured by ultrasound to assess changes. Researchers will also collect data on inflammatory and metabolic biomarkers. The study includes regular assessments and aims to track muscle and health recovery outcomes following SAH, under the sponsorship of the University of Maryland, Baltimore.
CONDITIONS
Brief Title
Impact of NMES and HPRO on Recovery After SAH- Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with aneurysmal subarachnoid hemorrhage (SAH)
- Aneurysmal repair performed within 48 hours of hemorrhage onset
- Age between 25 and 80 years old
- Expected to stay in the neurocritical care unit for more than 72 hours
- Admission Hunt Hess Grade of 2 or higher
- Modified Fisher score greater than 1
You will not qualify if you...
- SAH caused by trauma, arteriovenous malformation rupture, neoplasm, vasculitis, or other secondary causes
- Expected to survive less than one week post hemorrhage due to brain death or withdrawal of care
- Expected ICU stay less than 7 days
- Body mass index less than 15 or greater than 40 kg/m2
- Allergy to whey protein
- Evidence of lower extremity weakness or spasticity within 48 hours of injury
- Pre-morbid modified Rankin Score greater than 1
- Known pregnancy
- Active malignancy
- Diagnosis of inflammatory disorder
- Presence of neuromuscular disorder
- Chronic renal insufficiency or acute kidney injury with GFR below 30 mL/min/1.73m2
- Liver insufficiency with AST/ALT levels more than 2.5 times upper normal limits
- Ongoing seizure activity at enrollment
- Prisoner status
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 14 days
Participants receive neuromuscular electrical stimulation and/or high protein supplementation according to their assigned group during the study period.
Daily sessions for up to 14 days
Trial Site Locations
Total: 1 location
1
University of Maryland Medical Center
Baltimore, Maryland, United States, 21201
Actively Recruiting
Research Team
N
Neeraj Badjatia, MD MSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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