Evaluating Non-Surgical Periodontal Treatment Effects on Early Endothelial Dysfunction in Patients with Peri-Implantitis or Peri-Implant Mucositis

What this Trial Is About

Researchers are evaluating the effects of non-surgical periodontal treatment on early signs of endothelial dysfunction in people with peri-implantitis or peri-implant mucositis who do not have cardiovascular disease. This double-blind randomized-controlled clinical trial includes 90 participants divided into three groups 30 with peri-implantitis, 30 with peri-implant mucositis, and 30 healthy controls without a history of periodontitis. The study aims to understand how periodontal health impacts cardiovascular function in these conditions. The treatment being studied is non-surgical periodontal therapy, specifically subgingival biofilm ultrasonic debridement. Participants are grouped based on their diagnosis, with one group receiving treatment for peri-implantitis, another for peri-implant mucositis, and a healthy control group without intervention. The study follows international guidelines for diagnosis and treatment and compares cardiovascular and periodontal parameters before and after the treatment. Participants will undergo assessments including clinical periodontal exams, blood tests, and non-invasive ultrasound measurements of cardiovascular health. Outcome measures include pulse wave velocity, carotid intima-media thickness, distensibility coefficient, and levels of advanced glycation end products, all evaluated at baseline and 8 weeks after treatment. The study monitors these parameters to assess the impact of periodontal therapy on early endothelial dysfunction over the study duration.

Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis