Actively Recruiting
Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes
Led by University of Virginia · Updated on 2026-05-07
60
Participants Needed
1
Research Sites
226 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is: * To see if insulin resistance (how sensitive your muscle tissue is to insulin) is associated with lower cardio fitness in people with Type 1 diabetes compared to healthy controls, before and after a High Intensity Interval Training (HIIT) exercise program. * To see if being overweight and having Type 1 diabetes is associated with lower cardio fitness compared to overweight healthy controls, before and after a HIIT exercise program.
CONDITIONS
Official Title
Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 21 to 50 years
- For people with Type 1 diabetes: diagnosed for 5 or more years and HbA1c 8.5% or less while using multiple daily insulin injections or an insulin pump
- Body mass index (BMI) between 19 and 27 kg/m2 for control and Type 1 diabetes groups
- BMI between 30 and 40 kg/m2 (27.5 to 37.5 for Asian Americans) for obesity and Type 1 diabetes plus obesity groups
- BMI limited to 40 kg/m2 (37.5 for Asian Americans) for easier vascular access and cardiac imaging
- Stable use of non-insulin medications for more than 6 months, except estrogen/progesterone medications which must be stopped at least 3 months before the study (intrauterine devices allowed due to limited absorption)
You will not qualify if you...
- Acute or chronic disease other than Type 1 diabetes or obesity
- History of microvascular or macrovascular diabetes complications
- History of diabetic ketoacidosis within the past 24 months
- History of hypoglycemia unawareness
- Regularly active with more than 20 minutes of moderate or high intensity exercise twice a week recently
- Current or recent smokers who quit less than 5 years ago
- High triglyceride levels above 400 mg/dl
- Using vasoactive medications like calcium channel blockers, ACE inhibitors, angiotensin receptor blockers, nitrates, alpha or beta blockers, or diuretics
- Females who have taken oral contraceptives in the past 3 months
- History of significant metabolic, cardiac, cerebrovascular, blood, lung, digestive, liver, kidney, endocrine disease, or cancer
- Pregnant or nursing women
- Musculoskeletal problems that prevent exercise testing or training
- History of gastroparesis
- Oxygen saturation below 90% measured by pulse oximetry
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Virginia
Charlottesville, Virginia, United States, 22908
Actively Recruiting
Research Team
L
Lee Hartline, MEd
CONTACT
Z
Zhenqi Liu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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