Actively Recruiting
Impact of Omega 3 in Alcohol Use Disorder
Led by Université Catholique de Louvain · Updated on 2023-06-22
100
Participants Needed
1
Research Sites
236 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate the biological pathways underlying the beneficial effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on mental health in patients with alcohol use disorder. The main questions this study aims to answer are: * Can n-3 PUFA improve mood disorders (depression, anxiety), craving for alcohol, cognitive impairments and sociability disorders ? * Are the beneficial effects of n-3 PUFAs due to a modification of the gut microbiota and/or the inflammatory status? Participants will : * take a supplementation of omega-3 or placebo during 3 months * do a brain MRI * be interviewed for a dietary anamnesis * provide blood, stool and saliva samples * perform psychological tests and neuropsychological tasks Researchers will compare active comparator (omega-3) with placebo comparator (olive oil) to see if omega-3 can have a beneficial effect on AUD patients.
CONDITIONS
Official Title
Impact of Omega 3 in Alcohol Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of alcohol use disorder (at least 4 DSM-5 criteria)
- Patient admitted for a 3-week alcohol withdrawal program
- Male or female gender
- Age between 18 and 70 years old
- French speaking
- Alcohol consumption within 48 hours before admission
You will not qualify if you...
- Presence of another addiction except smoking and cannabis use
- Psychiatric comorbidity (axis 1 DSM-5)
- Use of antibiotics, probiotics, or fiber supplements within the last 2 months
- Use of omega-3 supplements within the last 2 months
- Use of oral anti-coagulants within the last 2 months
- Use of double anti-platelet therapy within the last 2 months
- Coagulation disorders
- Use of non-steroidal anti-inflammatory drugs or glucocorticoids within the last month
- Morbid obesity with body mass index over 35 kg/m2
- History of bariatric surgery
- Type 1 diabetes or unstable type 2 diabetes
- Chronic inflammatory diseases
- Cancer diagnosed less than 5 years ago
- Presence of cirrhosis (Fibroscan F4 and echodoppler confirmed)
- Known allergy to fish and seafood
- Any other medical condition that contraindicates participation as judged by the principal investigator
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Trial Site Locations
Total: 1 location
1
Cliniques universitaires Saint Luc
Brussels, Belgium, 1200
Actively Recruiting
Research Team
S
Sophie Leclercq, PhD
CONTACT
M
Marie Mornard
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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