IMPACT 360 Study for Parkinsons Disease Combined Exercise, Mindfulness, and Nutrition Intervention

What this Trial Is About

Researchers are evaluating the effects of a combined program of exercise, mindfulness, and nutrition on key health indicators in people aged 40 to 85 with Parkinsons disease or REM Sleep Behavior Disorder. This study aims to understand how these lifestyle changes affect brain health, cognition, inflammation, sleep, fitness, cardiovascular health, social and mental well-being, and microbiome diversity using a comprehensive 360 degree approach. The trial follows a partial crossover design where all participants eventually receive the intervention. The intervention includes online exercise classes three times a week for six months, guided meditation following exercise, mindfulness-based stress reduction classes, and biweekly nutrition and cooking sessions with a dietician. Participants are randomized to start the intervention immediately or after a six-month waitlist period during which they continue usual care. Physical activity and sleep are monitored using wearable devices throughout the study. Participants will complete assessments at baseline, after six months, and at the end of the intervention. Evaluations include cognitive tests, blood tests for inflammation markers, brain imaging, sleep quality assessments, physical fitness tests, cardiovascular measures, and questionnaires on mental and social health. Optional glucose metabolism testing is also offered. The study monitors adherence via wearable technology and questionnaires, with total participation lasting up to 12 months depending on group assignment.

IMPACT 360 for Parkinson's Disease