Actively Recruiting
Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound
Led by Ain Shams University · Updated on 2025-08-29
30
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effect of patient positioning during chemical pleurodesis with doxycycline in people with malignant pleural effusion. This study aims to compare the outcomes of pleurodesis when patients are rotated versus when they are not, using chest ultrasound to assess the results. The research addresses the common practice of patient rotation during pleurodesis and seeks to verify its benefit since doxycycline distribution in the pleural space may not require such movement. The study involves administering chemical pleurodesis using oral doxycycline powder, a widely available and cost-effective option. Participants will be randomly assigned to one of two groups: one group will receive pleurodesis followed by patient rotation (side to side and front to back for 30 minutes each), and the other group will not be rotated after the procedure. This randomized design helps to compare the efficacy and safety of pleurodesis with and without rotation. During the study, participants will undergo chest ultrasound assessments immediately and one month after pleurodesis to measure pleural adhesion scores. Pain will also be evaluated right after the procedure using a non-verbal pain score. The study will monitor safety and comfort, with follow-ups to observe patient outcomes over time. The total duration of participation includes immediate and one-month post-procedure evaluations to assess the success of the treatment and patient experience.
CONDITIONS
Brief Title
Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients admitted to the Chest department at Ain-Shams University Hospitals with malignant pleural effusions who are candidates for pleurodesis
You will not qualify if you...
- Presence of multiloculated pleural fluid
- Previous failed pleurodesis
- Liver failure
- Renal failure
- Congestive heart failure
- Prolonged use of steroids or NSAIDs
- Refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of pleurodesis plus 30 minutes post-procedure
Participants undergo pleurodesis using doxycycline and are randomized to either rotation or no rotation after the procedure.
1 treatment visit (in-person)
Duration - 1 month
Participants are assessed immediately and after one month to measure pleural adhesion and pain scores.
2 follow-up visits (immediately post-pleurodesis and at 1 month)
Trial Site Locations
Total: 1 location
1
Ain Shams university
Cairo, Egypt
Actively Recruiting
Research Team
H
Hieba G Ezzelregal, MD
A
Ahmed M Abdelsamad
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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