Studying the Effect of Patient Position on Chemical Pleurodesis Using Doxycycline for Malignant Pleural Effusion by Chest Ultrasound

What this Trial Is About

Researchers are evaluating the effect of patient positioning during chemical pleurodesis with doxycycline in people with malignant pleural effusion. This study aims to compare the outcomes of pleurodesis when patients are rotated versus when they are not, using chest ultrasound to assess the results. The research addresses the common practice of patient rotation during pleurodesis and seeks to verify its benefit since doxycycline distribution in the pleural space may not require such movement. The study involves administering chemical pleurodesis using oral doxycycline powder, a widely available and cost-effective option. Participants will be randomly assigned to one of two groups one group will receive pleurodesis followed by patient rotation side to side and front to back for 30 minutes each, and the other group will not be rotated after the procedure. This randomized design helps to compare the efficacy and safety of pleurodesis with and without rotation. During the study, participants will undergo chest ultrasound assessments immediately and one month after pleurodesis to measure pleural adhesion scores. Pain will also be evaluated right after the procedure using a non-verbal pain score. The study will monitor safety and comfort, with follow-ups to observe patient outcomes over time. The total duration of participation includes immediate and one-month post-procedure evaluations to assess the success of the treatment and patient experience.

Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound