Actively Recruiting
The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS
Led by Vietnam Military Medical University · Updated on 2024-12-13
76
Participants Needed
1
Research Sites
123 weeks
Total Duration
On this page
Sponsors
V
Vietnam Military Medical University
Lead Sponsor
H
Hanoi Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Acute respiratory distress syndrome (ARDS) in its moderate to severe forms is associated with high mortality. Mechanical ventilation (MV) remains the cornerstone of ARDS management but carries a significant risk of ventilator-induced lung injury (VILI). Positive end-expiratory pressure (PEEP), a fundamental component of MV, is widely utilized in clinical practice; however, optimal PEEP selection for patients with moderate to severe ARDS remains a complex and unresolved challenge. Electrical impedance tomography (EIT), a bedside imaging modality that evaluates regional ventilation distribution, offers a means of individualizing PEEP settings in mechanically ventilated patients. By balancing the competing risks of alveolar overdistension and collapse, EIT facilitates precision in PEEP titration. This study compares the impact of EIT-guided PEEP selection versus the conventional low FiO2-PEEP table on blood oxygenation and pulmonary mechanics.
CONDITIONS
Official Title
The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosed with moderate to severe ARDS (PaO2/FiO2 60 200 mmHg)
- Currently intubated and receiving mechanical ventilation
- Receiving continuous sedation with or without paralysis
You will not qualify if you...
- Pneumothorax that is undrained or recently developed
- Unstable blood pressure with mean arterial pressure below 60 mmHg despite treatment
- Heart rate below 60 beats per minute
- Contraindications for EIT such as pacemakers, automatic external defibrillators, chest trauma, or recent chest surgery limiting EIT belt use
- Pregnancy
- Severe neuromuscular disease
AI-Screening
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Trial Site Locations
Total: 1 location
1
Intensive Care Center, Bach Mai Hospital
Hanoi, Vietnam
Actively Recruiting
Research Team
T
Trung Van Dinh, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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