Actively Recruiting
Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery
Led by Peking University First Hospital · Updated on 2026-04-13
316
Participants Needed
1
Research Sites
64 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
For patients after surgery, quality of recovery has significant impacts on the prognosis, quality of life, and rational allocation of medical resources. Dexmedetomidine and esketamine have each been used during the perioperative period and improved postoperative analgesia and subjective sleep quality. This 2x2 factorial trial is designed to explore the effects of dexmedetomidine, esketamine, and their combination on the quality of recovery in patients recovering from surgery under general anesthesia.
CONDITIONS
Official Title
Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or over
- Scheduled to undergo surgery under general anesthesia, with an expected surgical duration of at least 1 hour
- Required patient-controlled intravenous analgesia after surgery
You will not qualify if you...
- Unable to communicate preoperatively due to visual, auditory, or verbal barriers or other reasons
- Severe bradycardia (heart rate <50 bpm), sick sinus syndrome, or grade 2 or higher atrioventricular block without pacemaker
- History of hyperthyroidism or pheochromocytoma
- History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension
- Intracranial tumor or neurosurgery
- Severe liver dysfunction (Child-Pugh class C), renal failure (requiring renal replacement therapy), or American Society of Anesthesiologists class IV or higher
- Enrolled in other clinical studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
Research Team
D
Dong-Xin Wang, MD, PhD
CONTACT
K
Kun Wang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
PREVENTION
Number of Arms
4
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