Actively Recruiting
Impact of Pilates Exercises on Bone Mineral Density in Breast Cancer Survivors Receiving Hormonal Therapy
Led by Benha University · Updated on 2026-01-15
60
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Breast cancer survivors who are receiving hormonal therapy with aromatase inhibitors face a high risk of bone loss and osteoporosis due to lower estrogen levels. This research aims to study whether Pilates exercises can improve bone health in these patients by focusing on bone mineral density (BMD) at the lumbar spine and hip. The study responds to a lack of randomized trials testing Pilates specifically for bone outcomes in this group. The study involves a 12-week Pilates program consisting of mat-based exercises, potentially using light equipment like resistance bands and small weights. Participants will exercise for 60 minutes, three times a week, with sessions guided by a physiotherapist experienced in cancer rehabilitation. Alongside Pilates, all participants will receive daily calcium and vitamin D supplements as part of standard osteoporosis care. The program will gradually increase in difficulty based on each participant's tolerance. Participants will be assessed at the start and after 12 weeks for bone mineral density and quality of life related to breast cancer therapy using questionnaires. They will attend supervised exercise sessions and receive supplementation throughout the study. Researchers will monitor bone health changes and overall functional status during this period. Total participation spans approximately three months, focusing on the effects of Pilates combined with supplements on bone strength and patient well-being.
CONDITIONS
Brief Title
Impact of Pilates Exercises on Bone Mineral Density in Breast Cancer Survivors Receiving Hormonal Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female breast cancer survivors aged 40 to 60 years
- Histologically confirmed stage I to III breast cancer
- Currently receiving hormonal therapy (aromatase inhibitors) for at least 3 months
- At risk of osteoporosis or low bone mineral density with T-score ≤ -1.0 at lumbar spine or hip
- Medically cleared for low-to-moderate intensity Pilates exercise
- Able to attend supervised Pilates sessions three times per week for 12 weeks
- Willing and able to provide written informed consent
You will not qualify if you...
- Metastatic (stage IV) or recurrent breast cancer
- History of osteoporotic fractures within the past 12 months
- Severe cardiovascular, respiratory, or musculoskeletal conditions that prevent exercise
- Uncontrolled hypertension, diabetes, or thyroid disorders
- Current use of corticosteroids
- Active bone metabolic diseases other than osteoporosis (e.g., Paget's disease, osteomalacia)
- Severe cognitive impairment or psychiatric illness preventing adherence to exercise or supplementation
- Known allergy or intolerance to calcium or vitamin D supplements
- Participation in another clinical trial involving exercise or bone-targeted treatment within the last 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 12 weeks
Participants engage in a 12-week Pilates exercise program combined with daily calcium and vitamin D supplementation to evaluate effects on bone mineral density.
Three supervised Pilates sessions per week
Trial Site Locations
Total: 1 location
1
Outpatient clinic, faculty of Physical Therapy, Benha university
Banhā, Benha, Egypt, 11603
Actively Recruiting
Research Team
M
Mahmoud Hamada Mohamed Associate Professor, Ph.D
A
Ahmed Mounir Salama Associate Professor, Ph.D
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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