Actively Recruiting
Impact of Prebiotics in Ulcerative Colitis
Led by University of California, Los Angeles · Updated on 2026-02-27
70
Participants Needed
1
Research Sites
181 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The cause of inflammatory bowel disease (IBD) is currently unknown, although partly attributed to interactions among genetic risk polymorphisms, environmental factors, gut microbiome, and host immunity. Diet, particularly those with plant-based products, have been shown in prior research to improve gut microbial composition, which has been linked to different IBD-related outcomes. This study is interested in evaluating the impact of prebiotics on gut microbiome composition and gut health in patients with IBD. Dietary composition will be assessed at baseline and over the course of 16 weeks. Participants will be randomized to either consume an 8-week course of prebiotic supplementation beginning at week 0 or week 8. Stool samples will be collected at weeks 0 and 8. The stool will be analyzed for cross-sectional and longitudinal fecal microbial changes associated with different prebiotic and diet consumption patterns in the context of heterogeneous disease characteristics.
CONDITIONS
Official Title
Impact of Prebiotics in Ulcerative Colitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 18 to 85 years old
- History of biopsy-proven ulcerative colitis
- Active symptoms with Simple Clinical Colitis Activity Index (SCCAI) greater than 2
- Use of 5-aminosalicylates, immunomodulators, or corticosteroids allowed if no dose changes in past 30 days
- Use of biologic therapy allowed if no dose changes in past 60 days
- Prior use of probiotics or dietary supplements allowed but must be stopped during the trial
You will not qualify if you...
- Prior colectomy surgery
- Current hospitalization
- Urgent need for abdominal surgery
- Unstable major medical conditions
- Active cancer under treatment
- Active alcohol or non-cannabinoid substance abuse
- Pregnancy or lactation
- Concerns about ability to comply with the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UCLA
Los Angeles, California, United States, 90095
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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