Impact of a Predetermined Day 5 Versus Day 6 Embryo Transfer on Clinical Pregnancy Rate After ICSI Treatment

What this Trial Is About

This research aims to compare the effects of transferring embryos on day 5 versus day 6 after intracytoplasmic sperm injection (ICSI) treatment in women facing infertility or reproductive issues. The study is prospective and multicenter, including participants from three fertility centers. It investigates whether delaying embryo transfer to day 6 influences the clinical pregnancy rate and abortion rate, as no prior prospective studies have directly compared these two specific timing options. Participants are divided into two groups: a control group receiving embryo transfers on day 5 and a study group receiving transfers on day 6. The control group includes patients with oocyte pick-up on various days leading to day 5 transfers, while the study group includes patients with oocyte pick-up on a specific day leading to day 6 transfer. This design allows comparison of the clinical outcomes between predetermined embryo transfers on day 5 and day 6 after ICSI. During the study, clinical pregnancy is assessed by detecting a gestational sac four weeks after embryo transfer, which is the primary outcome. The abortion rate per clinical pregnancy is monitored throughout the ongoing pregnancy as a secondary outcome. Data collection takes place at multiple fertility centers, and the study includes only women aged 18 or older undergoing their first ICSI cycle with a single embryo transfer. Participants are observed through the pregnancy period to evaluate these outcomes.

Impact of a Predetermined Day 5 ET vs. a Predetermined Day 6 ET on Clinical Pregnancy Rate After ICSI Treatment