Actively Recruiting
The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial
Led by Dana-Farber Cancer Institute · Updated on 2025-11-24
40
Participants Needed
2
Research Sites
137 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine the feasibility of a prehabilitation program for participants diagnosed with rectal cancer undergoing neoadjuvant chemotherapy and/or radiation, followed by surgical resection. The names of the groups in this research study are: * Group A: Prehabilitation program * Group B: Usual Care
CONDITIONS
Official Title
The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older at enrollment
- English-speaking
- Diagnosis of clinical stage II or III rectal cancer
- Planned, ongoing, or recently completed neoadjuvant treatment including chemoradiation, total neoadjuvant therapy, or chemotherapy only
- Able to understand study procedures and provide informed consent
You will not qualify if you...
- Known distant metastatic disease at diagnosis
- Unable to perform exercise testing due to functional incapacity
- Comorbid conditions or cognitive/physical impairments that contraindicate exercise
- Currently being treated for a secondary primary tumor in addition to rectal cancer
- Enrolled in another clinical trial that would prevent participation in this study's tasks
- Participating in more than 60 minutes of moderate-to-vigorous aerobic exercise per week over the past month
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
Actively Recruiting
2
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
J
Jeffrey Meyerhardt, MD, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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