Study on Preoperative Opioid-Free Multimodal Pain Relief to Speed Up Urination Trial After Minor Female Urogynecologic Surgeries

What this Trial Is About

Researchers are evaluating the effect of preoperative opioid-free pain relief on the time it takes for patients to resume normal bladder function after same-day minor urogynecologic surgeries. This randomized controlled trial compares two groups one receiving acetaminophen alone and the other receiving a combination of acetaminophen, celecoxib, and gabapentin before surgery. The goal is to see if the combination reduces the time to trial of void in female patients undergoing these procedures. Participants are randomly assigned to receive either a single oral dose of 1000 mg acetaminophen alone or a combination of 1000 mg acetaminophen, 400 mg celecoxib, and 300 mg gabapentin before their urogynecologic surgery. These surgeries include procedures such as midurethral sling, periurethral bulking injections, anterior repair, posterior repair, and perineorrhaphy. The study period lasts for about two years to complete the follow-up. During the study, researchers will monitor the time until participants begin an active trial of void following surgery. Participants must be female, over 18 years of age, and in good general health to take oral medications. They will be assessed for safety and adherence to the study treatment. The primary outcome measure is the time to initiation of active trial of void, tracked through study completion. This study is sponsored by Northwell Health and includes regular monitoring without masking or blinding.

Impact of Preoperative Opioid-free Multimodal Analgesia on Time to Trial of Void in Ambulatory Urogynecologic Surgeries