Impact of the Presence of the Corpus Luteum on Pregnancies Obtained Through Frozen Embryo Transfer: a Prospective Randomized Controlled Study

What this Trial Is About

Researchers are studying pregnancies achieved through programmed frozen embryo transfer cycles (PC-FET) and modified natural frozen embryo transfer (mNC-FET) to see if there are differences in how the placenta and blood vessels function, as well as how the mother's heart and the baby's growth and brain development are affected. They are particularly interested in how these differences relate to substances produced by the Corpus Luteum, which play roles in blood vessel and tissue growth. This study is a prospective randomized controlled trial sponsored by Fundacion Clinic per a la Recerca Biome9dica. The trial compares three groups: pregnancies without the Corpus Luteum using estradiol and progesterone (PC-FET), pregnancies with the Corpus Luteum using Ovitrelle (Hcg 250 mcg) (NC-FET), and spontaneous pregnancies with no intervention as a control. Participants are randomly assigned to one of these groups. Treatments involve hormone support or natural cycle preparation depending on the group. The study follows participants up to 10 months, with assessments at various points including delivery. Participants undergo multiple evaluations including blood tests to measure hormone levels like Relaxin-2, heart ultrasounds to examine fetal heart function (MAPSE), and tracking of fetal growth at 12, 20, 28, 32, and 36 weeks of pregnancy. Data on the placenta and newborn are collected at delivery. Maternal cardiovascular health is monitored through echocardiography and endothelial function tests. The study also collects baseline preconception parameters. Overall, the involvement spans from before embryo transfer through pregnancy and up to 10 months, with detailed monitoring of mother and baby health.

Impact of the Presence of the Corpus Luteum on Pregnancies Obtained Through Frozen Embryo Transfer(FET)