Actively Recruiting
Impact of Pringle Maneuver on Postoperative Gallbladder Diseases After Hepatectomy
Led by West China Hospital · Updated on 2026-03-05
2000
Participants Needed
8
Research Sites
21 weeks
Total Duration
On this page
Sponsors
W
West China Hospital
Lead Sponsor
F
First Affiliated Hospital of Harbin Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The liver is an organ with a rich blood supply. During liver surgery (hepatectomy), surgeons often temporarily clamp the blood vessels supplying the liver to maintain a clear surgical field and reduce bleeding. This common technique is known as the Pringle maneuver. However, this maneuver also temporarily cuts off the blood supply to the gallbladder. Currently, doctors debate whether to routinely remove a healthy gallbladder during liver surgery to prevent future gallbladder problems, or to preserve it. The primary purpose of this multicenter retrospective cohort study is to evaluate whether using the Pringle maneuver during liver surgery increases the risk of patients developing gallbladder diseases (such as gallstones or inflammation) later on. Researchers will review the past medical records of patients who underwent liver surgery with their gallbladder preserved between January 2012 and January 2022. By comparing patients who had the Pringle maneuver with those who did not, the study aims to provide reliable clinical evidence to help surgeons make better decisions about whether to preserve or remove the gallbladder during liver surgery.
CONDITIONS
Official Title
Impact of Pringle Maneuver on Postoperative Gallbladder Diseases After Hepatectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 85 years
- Definite diagnosis of hepatic solid lesions confirmed by imaging or pathology
- Underwent elective hepatectomy with gallbladder preservation
- Preoperative liver function classified as Child-Pugh class A or B
- Preoperative physical status classified as ASA class I, II, or III
You will not qualify if you...
- Preexisting biliary tract diseases such as gallstones, biliary inflammation, or tumors
- History of previous upper abdominal surgery
- Use of non-hepatic inflow occlusion methods during surgery
- Long-term use of hormone replacement therapy, somatostatin or its analogues, or oral contraceptives
- Loss to follow-up or missing important postoperative data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
The First Affiliated Hospital of University of Science and Technology of China
Hefei, Anhui, China
Actively Recruiting
2
Xinqiao Hospital of Army Medical Universit
Chongqing, Chongqing Municipality, China
Actively Recruiting
3
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
Actively Recruiting
4
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, China
Actively Recruiting
5
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China
Actively Recruiting
6
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Actively Recruiting
7
Nanjing Drum Tower Hospital
Nanjing, Jiangsu, China
Actively Recruiting
8
Tianjin Medical University Cancer Institute and Hospital
Tianjin, Tianjin Municipality, China
Actively Recruiting
Research Team
J
Jiwei Huang
CONTACT
J
Jun Ji
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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