Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study.
Ayano Imai, Yuriko Oda, Naoki Ito...
https://pubmed.ncbi.nlm.nih.gov/29495607Actively Recruiting
Phase Not Applicable
Age: 21Years - 59Years
All Genders
Healthy Volunteers
ID06454942
Impact of Regular Consumption of Eggs and Nutrients Fortified Eggs on Eczema Condition in Singapore Individuals With Eczema
Led by National University of Singapore · Updated on 2024-07-19
44
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
Sponsors
N
National University of Singapore
Lead Sponsor
N
National University Hospital, Singapore
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of daily consumption of nutrient-fortified eggs compared to regular eggs on eczema in adults aged 21 to 59 in Singapore. The study aims to see if eating these eggs can improve eczema symptoms and related health markers. This is a double-blind, randomized study involving individuals with mild to moderate eczema who are otherwise healthy and have a normal body mass index. Participants will be randomly assigned to one of two groups: one consuming two regular eggs daily and the other consuming two nutrient-fortified eggs daily, both alongside their usual diet. Both groups receive personalized dietary counseling and written instructions from research dietitians and trained staff. The study lasts for 12 weeks, during which the participants follow their assigned egg consumption. Throughout the study, participants will undergo regular assessments at weeks 0, 3, 6, 9, and 12. These include skin evaluations using questionnaires such as the SCORAD Index, EASI scoring, and Dermatology Life Quality Index, as well as measurements of skin and blood carotenoid levels. Eye health is also assessed through various tests, and blood samples are collected to analyze inflammatory and metabolic biomarkers. The study monitors changes in skin, eye health, and other biological markers to understand the impact of the eggs on eczema and overall health.
CONDITIONS
Brief Title
Impact of Regular Consumption of Eggs and Nutrients Fortified Eggs on Eczema Condition in Singapore Individuals
Who Can Participate
Age: 21Years - 59Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Able to read and give informed consent in English
- Male and female participants, aged between 21 and 59 inclusive
- Healthy individuals with no underlying conditions or regular medications
- Body mass index (BMI) between 18.5 and 25 kg/m2
- Mild to moderate eczema severity as determined by screening questionnaires
You will not qualify if you...
- Significant body weight change (3 kg or more) in the past 3 months
- High-intensity exercise more than 3 hours per week in the past 3 months
- Known allergy to eggs
- Taking dietary supplements that could affect study results
- Having gastrointestinal disorders unsuitable for the study
- Current smokers
- Consuming more than 2 alcoholic drinks per day
- Taking lipid-lowering or blood pressure medications for less than 3 years
- Pregnant, lactating, or planning to conceive within 6 months
- Unwilling to stop eczema medications during the study
- Professional or family ties with research team members
- Participating in another clinical study
- Blindness in one or both eyes or eye diseases affecting study results
- Poor quality macular pigment optical density results at screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening visit (in-person)
Treatment
Duration - 12 weeks
Participants consume either nutrient-fortified eggs or regular eggs daily alongside their habitual diet while receiving dietary counselling and instructions from research staff.
Visits at Week 0, Week 3, Week 6, Week 9, and Week 12 for assessments
Trial Site Locations
Total: 1 location
1
Department of Food Science and Techonology, Block S13
Singapore, Singapore, 117550
Actively Recruiting
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Research Team
Y
Yuxin LIANG
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
The Effect of Lutein/Zeaxanthin Intake on Human Macular Pigment Optical Density: A Systematic Review and Meta-Analysis.
Lisa M Wilson, Saraniya Tharmarajah, Yuanxi Jia...
https://pubmed.ncbi.nlm.nih.gov/34157098