Actively Recruiting
Impact of RFA on Esophageal Distensibility and Mucosal Impedance
Led by Mayo Clinic · Updated on 2026-03-30
10
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients undergoing ablative therapy for management of dysplastic Barrett's Esophagus (BE) will have decreased distensibility over the course of treatment, but improvement in mucosal impedance as BE epithelia is replaced by neosquamous epithelia. This information may lead to further research in predicting therapeutic response and complications. The purpose of this research is to collect information while measuring changes related to the esophagus in patients that receive radiofrequency ablation (RFA) for dysplastic Barrett's Esophagus (BE) or esophageal cancer. Study participation includes measurements of the esophagus with the use of two different devices. This takes place during clinically indicated upper endoscopies during the timeframe the participant is receiving RFA treatments. This process will take up to an additional 10 minutes during the upper endoscopy and be done while the participant is sedated.
CONDITIONS
Official Title
Impact of RFA on Esophageal Distensibility and Mucosal Impedance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female 18 years of age or older
- Confirmed diagnosis of Barrett's Esophagus with dysplasia or intramucosal carcinoma
- Ability to take high-dose proton pump inhibitor therapy such as omeprazole 40 mg twice daily
- Willingness to undergo multiple rounds of endoscopic eradication therapy for Barrett's Esophagus management
You will not qualify if you...
- History of esophageal ablation
- History of esophageal stricture
- History of esophageal or gastric surgery
- Pregnancy
- History of esophageal cancer treated with radiation or chemotherapy
- History of achalasia
- History of delayed gastric emptying confirmed by a 4-hour gastric emptying study
- Received injection of glucagon like peptide 1 agonists within a few days prior to endoscopy
- Adults lacking the capacity to consent for themselves
AI-Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
M
Mariah J Robran
CONTACT
M
Michele L Johnson
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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