Study of Esophagus Changes During Radiofrequency Ablation in Adults with Dysplastic Barretts Esophagus

What this Trial Is About

Researchers are studying patients with dysplastic Barretts Esophagus BE who are receiving radiofrequency ablation RFA treatment. The goal is to observe how the esophagus changes during treatment, specifically looking at decreased distensibility and improved mucosal impedance as abnormal tissue is replaced by new tissue. This research aims to better understand treatment response and potential complications in these patients. Participants will receive RFA treatments using devices from the BarrX RFA System, including the Halo 360 circumferential balloon catheter or focal catheters Halo 90 or Halo 60. Treatments target specific areas of the esophagus depending on disease presence. Measurements of the esophagus will be taken with two devices during routine upper endoscopies while the participant is sedated. These extra measurements add about 10 minutes to the endoscopy. During the study, participants will be monitored up to four times every 12 weeks over one year. Researchers will measure changes in the esophageal distensibility index, diameter, and mucosal impedance to assess treatment effects. These evaluations occur during clinically indicated endoscopies as part of the participants care. The study is observational and led by the Mayo Clinic.

Impact of RFA on Esophageal Distensibility and Mucosal Impedance