Impact of Salovum and SPC Flakes on Cerebral Edema Caused by Brain Tumors

What this Trial Is About

Researchers are investigating the effects of Salovum4, an egg yolk powder rich in the antisecretory factor protein, and SPC4 flakes, specially processed oats, on cerebral edema and its symptoms in people with brain tumors like glioblastoma, cerebral metastases, and meningioma. The study aims to see if these dietary supplements can improve clinical symptoms caused by tumor-related brain swelling and reduce the swelling seen on MRI scans. It also examines the impact on patients with steroid-resistant and steroid-nave cerebral edema. Participants will take Salovum4, 11 grams three times daily for 14 days, then gradually reduce the dose over the next 14 days. Starting on day 7, they will also consume SPC4 flakes daily at 1 gram per kilogram of body weight. Patients with steroid-nave edema will be monitored daily as inpatients, and if no improvement occurs within 3 days, steroids will be started. Those with steroid-refractory edema will be evaluated after 7 days, with steroids adjusted if needed. MRI scans will assess edema changes at baseline and again at 14 or 28 days depending on steroid use. During the study, participants will be evaluated using neurological and cognitive scales, including the NANO scale for neurological symptoms, MOCA for cognitive function, and ECOG for performance status. MRI scans will measure edema volume and index. Researchers will track steroid medication doses and analyze changes over time to determine any effects of the interventions. The total involvement includes initial evaluation, 28 days of treatment and tapering, and follow-up assessments to ensure safety and measure outcomes.

Impact of Salovum® and SPC® Flakes on Brain Tumor Induced Edema