Actively Recruiting
Impact of Sensory, Motor and Vestibular Deficit on the Postural Stability of CMT Patients
Led by IRCCS San Raffaele · Updated on 2024-05-24
60
Participants Needed
1
Research Sites
108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Charcot-Marie-Tooth (CMT), a therapeutically orphan neuromuscular disease affecting one in 2,500 people, represents a challenge to the medical and scientific communities. Physiotherapeutic-rehabilitative strategies play a crucial role in the management of CMT, particularly addressing balance impairment, a key disabling symptom. However, clinical studies in this field are limited. Our study aims to investigate the impact of strengh and somatosensory deficits on static and dynamic balance in CMT patients. The Investigators also aim to explore the involvement of the vestibular system and its correlation with postural instability. Furthermore, the Investigators seek to evaluate relationships between neurochemical biomarkers offering valuable insights for future targeted clinical studies.
CONDITIONS
Official Title
Impact of Sensory, Motor and Vestibular Deficit on the Postural Stability of CMT Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of hereditary sensory-motor neuropathy (CMT) confirmed by genetic analysis
- Diagnosis of hereditary motor neuropathy (HMN) confirmed by genetic analysis
- Diagnosis of hereditary sensory neuropathy (HSN) confirmed by genetic analysis
- Diagnosis of hereditary distal myopathy (MD) confirmed by genetic analysis
- Diagnosis of acquired sensory neuropathy with anti-MAG antibody confirmed by clinical, neurophysiological, and serological assessment
- Healthy controls matched by disability level, age, and gender to CMT patients
You will not qualify if you...
- Unable to maintain an upright position without assistance
- Presence of systemic, neurological (other than the neuropathies and hereditary myopathies under study), psychiatric, orthopedic, or rheumatological diseases affecting evaluation
- Mini Mental State Examination (MMSE) score less than 28
- History of alcohol or substance abuse
- Participation in intensive motor rehabilitation programs within the last three months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Dept. of Neurology, IRCCS Ospedale San Raffaele
Milan, Italy, 20132
Actively Recruiting
Research Team
S
Stefano C Previtali, MD
CONTACT
B
Benedetta Sorrenti, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here