Actively Recruiting
Impact of Severe Obstructive Sleep Apnea-Hypopnea Syndrome on Auditory-Cognitive Processing
Led by Peking University First Hospital · Updated on 2025-08-07
100
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn how severe obstructive sleep apnea-hypopnea syndrome (OSAHS) affects the brain's ability to process sounds and attention in adults aged 20-60 years. The main questions it aims to answer are: 1. Does severe OSAHS change how the brain automatically detects sound changes during wakefulness? 2. Does severe OSAHS reduce people's ability to pay attention to important sounds when awake? 3. Can brainwave tests (Electroencephalogram, EEG) detect early signs of hearing-related cognitive problems in OSAHS patients before symptoms appear? Researchers will compare two groups: * 50 adults with severe OSAHS (diagnosed by sleep tests) * 50 healthy adults matched by age and gender Participants will: * Complete hearing tests (MoCA) * Undergo a 1-night sleep test (PSG) * Wear an EEG cap for 1.5-2 hours while listening to sounds in a quiet room: * Passive task: Relax (no response needed) * Active task: Press a button when hearing rare sounds * Receive ¥75/hour compensation for their time
CONDITIONS
Official Title
Impact of Severe Obstructive Sleep Apnea-Hypopnea Syndrome on Auditory-Cognitive Processing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 20 to 60 years
- Normal hearing (PTA 64 25 dB HL at 0.5, 1, 2, 4 kHz; Type A tympanogram)
- MoCA score 64 26
- Willing to complete EEG testing
- For OSAHS group: PSG-confirmed severe OSAHS (AHI > 30 events/hour)
- For control group: No snoring or sleep disorders reported
- For control group: No prior diagnosis of OSAHS
You will not qualify if you...
- History of schizophrenia, epilepsy, Parkinson's disease, traumatic brain injury, or language disorders
- History of middle or inner ear diseases such as otitis media or acoustic neuroma
- Cognitive impairment or depression/anxiety disorders
- Chronic steroid use
- Systemic inflammatory diseases or malignancies
- Pregnancy or suspected pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Peking University First Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
Research Team
C
Caifeng Xia, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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