Actively Recruiting
Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial
Led by Xijing Hospital · Updated on 2026-04-16
450
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The present study is a multicenter， randomized controlled clinical trial, which plans to enroll 450 diabetic patients aged more than 60 years. The participants will be randomly assigned in a 1:1 ratio and will receive either propofol or sevoflurane for intraoperative anesthesia maintenance to evaluate the impact of these two anesthetic drugs on postoperative delirium. The aim of our study is to explore whether the use of propofol for anesthesia maintenance in elderly diabetic patients undergoing elective non-cardiac major surgery can reduce the incidence of postoperative delirium. This study will provide new perspectives for improving perioperative management in elderly diabetic patients and optimizing anesthesia management strategies to reduce the risk of postoperative delirium.
CONDITIONS
Official Title
Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 years or older
- Scheduled for elective surgery expected to last 2 hours or more
- ASA grade I to III
- Voluntary participation with informed consent
- Diagnosed with diabetes mellitus
You will not qualify if you...
- Pre-operative body mass index 35 kg/m² or higher (Class II obesity or above)
- Severe liver dysfunction (Child-Pugh class C) or dialysis-dependent kidney dysfunction before surgery
- Known neurological or psychiatric diseases such as Parkinson's disease, depression, schizophrenia, or cognitive impairment like dementia
- Severe vision or hearing problems, language barriers, or inability to cooperate
- Long-term use of sedatives, antipsychotic drugs, or history of long-term alcohol abuse
- Neurosurgical patients
- Known allergy to study drugs or suspected propofol infusion syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Air Force Medical University
Xi’an, Shanxi, China, 710032
Actively Recruiting
Research Team
H
Huang Nie
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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