Actively Recruiting
Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial
Led by Xijing Hospital · Updated on 2026-04-16
450
Participants Needed
1
Research Sites
5 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of two anesthetic drugs, propofol and sevoflurane, on the risk of developing postoperative delirium in elderly patients with diabetes undergoing major non-cardiac surgery. This multicenter, randomized controlled trial aims to find out if using propofol for anesthesia maintenance can reduce the incidence of delirium after surgery. The study is designed to improve perioperative and anesthesia management strategies for older diabetic patients. Participants will be randomly assigned to one of two groups. One group will receive propofol combined with remifentanil (TIVA group) for anesthesia maintenance during surgery, while the other group will receive sevoflurane combined with remifentanil (VA group). Both treatments are given during the surgery, and the comparison will help determine their impact on postoperative delirium. During the study, researchers will monitor the occurrence, severity, and duration of delirium within the first 7 days after surgery. They will also track the length of hospital stay and measure blood glucose levels at several points before, during, and after surgery. Participants will be followed closely to assess these outcomes, and the total participation period includes the surgery and the first week of recovery.
CONDITIONS
Brief Title
Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 years or older
- Scheduled for elective surgery expected to last 2 hours or more
- ASA physical status grade I to III
- Voluntary participation with informed consent
- Diagnosis of diabetes mellitus
You will not qualify if you...
- Body mass index (BMI) 35 kg/m² or higher (Class II obesity or above)
- Severe liver dysfunction (Child-Pugh class C) or kidney failure requiring dialysis
- Known neurological or psychiatric disorders such as Parkinson's disease, depression, schizophrenia, or dementia
- Severe vision or hearing problems, language barriers, or inability to cooperate
- Long-term use of sedatives, antipsychotics, or history of long-term alcohol abuse
- Neurosurgical patients
- Allergy to study drugs or suspected propofol infusion syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of the surgery (expected 2 hours or more)
Participants receive anesthesia with either propofol and remifentanil or sevoflurane and remifentanil during surgery.
1 surgical procedure visit
Duration - 7 days
Participants are monitored for postoperative delirium and other recovery indicators during the first 7 days after surgery.
Daily visits or assessments for 7 days post-surgery
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Air Force Medical University
Xi’an, Shanxi, China, 710032
Actively Recruiting
Research Team
H
Huang Nie
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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