Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID05487053

The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement (AdORe - ACB)

Led by Negovsky Reanimatology Research Institute · Updated on 2026-04-15

220

Participants Needed

1

Research Sites

30 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are comparing two types of nerve blocks used for pain relief after total knee replacement surgery, a common treatment for late-stage knee osteoarthritis. The study focuses on the effectiveness and impact of single-shot adductor canal block versus continuous femoral nerve block, particularly looking at rehabilitation outcomes. The femoral nerve block is widely used but can cause muscle weakness and increase fall risk, while the adductor canal block may provide good pain relief without affecting muscle function. Participants will receive either a single-shot injection of ropivacaine in the adductor canal or a continuous infusion of local anesthetic near the femoral nerve through a catheter. The single-shot adductor canal block uses a 20 ml dose of 0.5% ropivacaine, while the continuous femoral nerve block involves an infusion of 0.2% ropivacaine at a rate between 4 ml/h and 10 ml/h. This randomized, triple-blind study evaluates these two methods in the context of postoperative analgesia following planned primary total knee replacement with neuraxial anesthesia. During the study, participants' ability to walk and perform mobility tests will be assessed on the first and second days after surgery, including measurements like ambulation distance and timed walk tests. Researchers will also monitor readiness for discharge and length of hospital stay up to 30 days postoperatively. The study aims to understand how each nerve block affects recovery and physical function during the early rehabilitation period after knee replacement surgery.

CONDITIONS

Brief Title

The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Planned primary total knee replacement
  • Planned neuraxial anesthesia
  • Written informed consent
Not Eligible

You will not qualify if you...

  • Urgent surgery
  • Planned revision total knee replacement
  • Known allergic reaction to anesthetics
  • Confirmed localized infection at the puncture sites
  • Confirmed localized tumor at the puncture sites
  • Peripheral neuropathy of the lower extremities
  • Parkinson's disease
  • Previously enrolled in this trial

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - Up to hospital discharge

Participants undergo total knee replacement surgery followed by postoperative analgesia with either a single-shot adductor canal block or a continuous femoral nerve block.

1 surgical procedure and daily assessments until discharge

Post-operative Follow-up

Duration - 30 days

Participants are assessed on various functional and mobility tests during the first 2 days after surgery, and monitored for recovery and readiness for discharge up to 30 days.

Visits on postoperative days 1 and 2, and follow-up assessments up to 30 days

Trial Site Locations

Total: 1 location

1

Clinical Hospital on Yauza

Moscow, Russia, 111033

Actively Recruiting

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Research Team

V

Valery Likhvantsev

L

Levan Berikashvili

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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