Actively Recruiting
Impact of Stress on Brain Energy Metabolism
Led by Rupert Lanzenberger · Updated on 2025-12-23
68
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
Sponsors
R
Rupert Lanzenberger
Lead Sponsor
U
University of Konstanz
Collaborating Sponsor
AI-Summary
What this Trial Is About
Background: Stress plays an essential role in the pathophysiology of mental disorders. However, individual differences in the vulnerability to acute and repeated stress are not well understood. Aim: This work aims to investigate individual differences in glucose metabolism and directional connectivity regulating the neuronal stress response. Design: 68 healthy volunteers will undergo two simultaneous PET/MRI measurements one week apart. Participants will complete the Montreal Imaging Stress Test during each measurement and in-between. Effects of stress on cognitive performance will be assessed using the n-back working memory task. Individual cortisol levels will be acquired to identify stress (non)responders as well as (non)habituators. Implications: This work will characterize differences between stress responders vs. non-responders and stress habituators vs. non-habituators in terms of energy metabolism and network connectivity. This individual difference in the stress response may represent an important cornerstone for future evaluation of patients with mental disorders.
CONDITIONS
Official Title
Impact of Stress on Brain Energy Metabolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 40 years
- Right-handedness
- Willingness and ability to sign the informed consent form
You will not qualify if you...
- History of or current physical, neurological, or psychiatric disorders
- History of or current substance abuse or use of medications such as antipsychotics, antidepressants, or antianxiety agents
- Pregnancy or current breastfeeding
- Contraindications for MRI scanning, including metal implants or dental implants causing artifacts
- Previous radiation exposure exceeding 30 mSv in the last 10 years or body weight over 105 kg
- Inability to follow the study protocol or instructions from the research team
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Psychiatry and Psychotherapy, Medical University of Vienna
Vienna, Austria
Actively Recruiting
Research Team
A
Andreas Hahn, Assoc.Prof.
CONTACT
R
Rupert Lanzenberger, Prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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