Actively Recruiting
Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
Led by Ball State University · Updated on 2025-07-31
20
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity. Additionally, the investigators are interested in if this response differs based on whether individuals with obesity have very few heart disease risk factors or several heart disease risk factors.
CONDITIONS
Official Title
Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 55 years
- Body mass index (BMI) of 30 kg/m2 or higher
- Having either 0-1 or 2 or more metabolic syndrome risk factors related to blood pressure, blood sugar, triglycerides, or HDL-cholesterol outside normal ranges
- Not pregnant or expecting pregnancy (females only)
- Not postmenopausal (females only)
- No diagnosis of advanced cardiometabolic diseases such as cardiovascular disease or type 2 diabetes
- No diagnosis of chronic inflammatory conditions like rheumatoid arthritis, inflammatory bowel disease, or diverticulosis/diverticulitis
- Do not regularly use anti-inflammatory drugs more than twice per week and willing to pause these medications for 3 days before lab visits
- Not taking weight-loss medications such as Ozempic or Wegovy
- Do not use tobacco or illicit drugs
- No antibiotic or probiotic use in the last month
- No dietary restrictions preventing fiber supplement consumption, like allergies or intolerance
- Do not have a pacemaker
- Able to lie on back in the dark for at least 10 minutes for vascular testing
You will not qualify if you...
- Not aged between 18 and 55 years
- Body mass index (BMI) less than 30 kg/m2
- Does not have either 0-1 or 2 or more metabolic syndrome risk factors outside normal ranges
- Pregnant or expecting pregnancy (females only)
- Postmenopausal (females only)
- Diagnosed with advanced cardiometabolic conditions such as cardiovascular disease or type 2 diabetes
- Diagnosed with chronic inflammatory conditions like rheumatoid arthritis, inflammatory bowel disease, or diverticulosis/diverticulitis
- Regular use of anti-inflammatory drugs more than twice per week and unwilling to pause these medications for 3 days before lab visits
- Taking weight-loss medications such as Ozempic or Wegovy
- Use of tobacco products or illicit drugs
- Use of antibiotics or probiotics in the last month
- Dietary restrictions preventing fiber supplement consumption, such as food allergies or intolerance
- Have a pacemaker
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Health Professions Building
Muncie, Indiana, United States, 47306
Actively Recruiting
Research Team
B
Bryant Keirns, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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