Actively Recruiting

Phase Not Applicable
Age: 40Years - 60Years
FEMALE
Healthy Volunteers
NCT07433049

Impact of Supplementation in Improving Metabolic Health Outcomes (ISMOS) Study

Led by Institute for Human Development and Potential (IHDP), Singapore · Updated on 2026-02-25

400

Participants Needed

1

Research Sites

101 weeks

Total Duration

On this page

Sponsors

I

Institute for Human Development and Potential (IHDP), Singapore

Lead Sponsor

H

HALEON

Collaborating Sponsor

AI-Summary

What this Trial Is About

This study investigates the role of multivitamin and multimineral (MVM) supplementation in improving metabolic, musculoskeletal, and mental health among midlife Asian women aged 40-60 years, a critical period marked by hormonal and physiological transitions from pre- to post-menopause. Evidence from the GUSTO cohort in Singapore has shown that higher plasma levels of vitamins B6, B9, B12, and D are associated with better metabolic profiles, insulin sensitivity, and mental wellbeing, while deficiencies are linked to increased metabolic and psychological risks. Given that vitamin insufficiency and central obesity are highly prevalent among Asian women even at lower BMI, this randomized, double-blind, placebo-controlled trial will evaluate whether 12 months of daily MVM supplementation can reduce MetaboAge and improve metabolic, mental, and muscle health outcomes compared with placebo. Findings will inform preventive strategies for extending health span and mitigating chronic disease risks among midlife women in Asia.

CONDITIONS

Official Title

Impact of Supplementation in Improving Metabolic Health Outcomes (ISMOS) Study

Who Can Participate

Age: 40Years - 60Years
FEMALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Women aged 40-60 years old
  • Chinese, Malay or Indian ethnicity
  • Body mass index (BMI) between 23.0 and 35.0 kg/m2
  • Proficient in English language
  • Willing to comply with study protocol and provide informed consent
Not Eligible

You will not qualify if you...

  • Pregnant or planning a pregnancy
  • Diagnosed with diabetes, Polycystic Ovary Syndrome (PCOS), autoimmune diseases, chronic organ failure, severe heart disease, eating disorders, or other medical conditions that may affect study outcomes
  • Fasting glucose value 7.0 mmol/L or higher
  • Active cancer or cancer treatment in the last 3 years
  • Participating in other nutritional intervention studies
  • Taking oral corticosteroids, antipsychotic, or weight loss drugs
  • Planned hospitalization in the next 12 months
  • Planning major diet changes in the next 12 months
  • Taking prescribed supplements containing 3 or more ingredients of the study product
  • Taking non-prescribed supplements containing 3 or more ingredients of the study product in the last 1 month

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Trial Site Locations

Total: 1 location

1

Institute for Human Development and Potential (IHDP)

Singapore, Singapore, 117597

Actively Recruiting

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Research Team

J

Johan Eriksson, MD

CONTACT

M

Mya Thway Tint, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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