Actively Recruiting
The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer
Led by Thomas Jefferson University · Updated on 2026-01-23
100
Participants Needed
4
Research Sites
330 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial compares the effect of pulmonary vein-first surgical technique to pulmonary artery-first surgical technique in decreasing circulating tumor cell deoxyribonucleic acid (ctDNA) in patients with stage I-III non-small cell lung cancer. Pulmonary vein first and pulmonary artery first surgical techniques are standard surgical techniques for the division of the blood vessels during lung resection surgery. Pulmonary vein-first surgical technique may reduce the risk of shedding tumor cells during surgery and influence long term overall survival.
CONDITIONS
Official Title
The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years of age or older with confirmed or suspected stage I-III non-small cell lung cancer
- Eligible and scheduled for surgical anatomic lung resection (e.g., lobectomy or segmentectomy) as routine clinical care
You will not qualify if you...
- Previous cancer diagnosis within 5 years except for ductal carcinoma in situ of the breast, superficial bladder cancer, non-melanoma skin cancer, or other malignancies not requiring treatment
- Preoperative chemotherapy, immunotherapy, or radiation therapy
- Receipt of perioperative blood transfusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Abington Memorial Hospital
Abington, Pennsylvania, United States, 19001
Actively Recruiting
2
Jefferson Health Northeast
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
3
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
4
Asplundh Cancer Pavilion at Jefferson Health
Willow Grove, Pennsylvania, United States, 19090
Actively Recruiting
Research Team
T
Tyler Grenda, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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