Assessing Eye and Surrounding Tissue Effects in Adults With Systemic Light Chain Amyloidosis

What this Trial Is About

Systemic Light Chain AL Amyloidosis is a rare disease caused by abnormal plasma cells producing proteins that deposit in tissues and organs such as the kidneys, heart, and eyes, leading to damage. This study aims to understand how AL amyloidosis affects the eyes and their surrounding tissues, to identify early eye signs of the disease. It is an observational study including patients with AL amyloidosis and healthy controls, sponsored by Zhongshan Ophthalmic Center, Sun Yat-sen University. The study compares two groups patients with systemic light chain amyloidosis and normal controls without systemic diseases. Patients with amyloidosis will have eye examinations every 2 months for a total of 4 visits over 6 months to observe ocular complications and disease progression. The control group consists of individuals without systemic disease for comparison. Participants will undergo various eye assessments including conjunctival mass, subconjunctival hemorrhage, retinal blood flow, visual field, intraocular pressure, and others at each visit. Researchers will track changes and complications in eye tissues over the 6-month follow-up period. The study aims to gather detailed information on eye involvement in AL amyloidosis and improve early diagnosis through these measures.

The Impact of Systemic Light Chain Amyloidosis on Eyes