Actively Recruiting
Impact of a TDM-guided ECPA Program for Optimizing Pharmacodynamic Target Attainment of Continuous Infusion Beta-lactam-based Regimen
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2024-12-05
65
Participants Needed
1
Research Sites
122 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Previous studies have clearly demonstrated a significant impact of optimised antibiotic therapy based on a TDM-guided approach in reducing the clinical and microbiological failure rate and in improving the achievement of an optimal pharmacokinetic/pharmacodynamic target. However, no study has yet evaluated this aspect in the specific scenario of liver transplant patients with documented infections with Gram-negative pathogens.
CONDITIONS
Official Title
Impact of a TDM-guided ECPA Program for Optimizing Pharmacodynamic Target Attainment of Continuous Infusion Beta-lactam-based Regimen
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult liver transplant recipients aged 18 years or older
- Documented Gram-negative infections occurring within 90 days after transplantation
- Receiving treatment with beta-lactam based antibiotic regimens
- Signed informed consent to participate in the study
You will not qualify if you...
- Beta-lactam antibiotic treatment lasting less than 48 hours
- Infection with Gram-negative bacteria resistant to all available beta-lactam classes
- Patients receiving palliative care or with a do-not-resuscitate order
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy, 40138
Actively Recruiting
Research Team
F
Federico Pea, MD
CONTACT
M
Milo Gatti, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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