Outcome measurement in functional neurological disorder: a systematic review and recommendations.
Susannah Pick, David G Anderson, Ali A Asadi-Pooya...
https://pubmed.ncbi.nlm.nih.gov/32111637Actively Recruiting
Age: 18Years +
All Genders
ID07527403
Impact of Theta Burst Repetitive Transcranial Magnetic Stimulation on the Patient's Self-reported Improvement in Their Motor Functional Neurological Disorder
Led by Hospital Center Guillaume Régnier · Updated on 2026-04-20
22
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Functional neurological disorder (FND) causes significant suffering and disability through neurological symptoms that affect daily functioning without clear anatomical causes. This research focuses on motor symptoms like abnormal movements or motor deficits and aims to evaluate the impact of repetitive transcranial magnetic stimulation (rTMS) on patients' perceptions of improvement. The study also explores effects on symptoms from a clinician's viewpoint, quality of life, mood symptoms, dissociation, sense of agency, and rTMS side effects. Participants receive 40 sessions of intermittent theta burst rTMS targeting the right temporo-parietal junction (rTPJ) over 10 days, with four sessions per day. This non-invasive treatment uses magnetic pulses to modify brain activity and connectivity and is guided by neuronavigation. The protocol is based on recent research showing potential benefits and brain changes with this method in motor FND patients. During the study, patients' symptoms are assessed before and after treatment using patient and clinical global impression scales, movement disorder ratings, mood and fatigue scales, dissociation and agency measures, and quality of life surveys. Side effects are monitored throughout. The primary outcome is the change in patient global impression of change one month after treatment. The total evaluation period extends to about three months. This observational study aims to deepen understanding of rTMS effects on motor FND symptoms and patient well-being.
CONDITIONS
Brief Title
Impact of Theta Burst Repetitive Transcranial Magnetic Stimulation on the Patient's Self-reported Improvement in Their Motor Functional Neurological Disorder
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients over 18 years old
- Diagnosed with functional neurological disorder affecting movement by a neurologist
- Indicated for validated neuronavigated repetitive transcranial magnetic stimulation treatment
- Have agreed to participate in the study
You will not qualify if you...
- Patients under legal protection such as guardianship, conservatorship, or trusteeship
- Patients deprived of their liberty
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 10 days
Participants receive 40 sessions of intermittent theta burst repetitive transcranial magnetic stimulation (rTMS) targeting the right temporo-parietal junction (rTPJ) over 10 days.
4 sessions per day
Follow-up
Duration - 1 month and 3 weeks
Participants are monitored to assess the impact of rTMS treatment on their symptoms and quality of life, including patient and physician impression of change and side effects.
Visits occur during this period for assessments
Trial Site Locations
Total: 1 location
1
Centre Hospitalier Guillaume Régnier
Rennes, France, 35000
Actively Recruiting
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Research Team
D
Dominique DRAPIER, PHD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Krystyna T Peterson, Robert Kosior, Benjamin P Meek...
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Mark Hallett, Selma Aybek, Barbara A Dworetzky...
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Irene Gonsalvez, Primavera Spagnolo, Barbara Dworetzky...
https://pubmed.ncbi.nlm.nih.gov/34950864Psychiatric Applications of Repetitive Transcranial Magnetic Stimulation.
Katharine G Marder, Tracy Barbour, Stephen Ferber...
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Christopher D Stephen, Vicki Fung, Codrin I Lungu...
https://pubmed.ncbi.nlm.nih.gov/33104173