Actively Recruiting
Impact of Thrombocytopenia and Platelet Transfusions on Neonatal Bleeding and Inflammation
Led by Boston Children's Hospital · Updated on 2024-05-16
160
Participants Needed
2
Research Sites
367 weeks
Total Duration
On this page
Sponsors
B
Boston Children's Hospital
Lead Sponsor
B
Beth Israel Deaconess Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a prospective observational study that was designed with the following two Specific Aims: 1. To determine whether the Immature Platelet Fraction percentage (IPF%) and the Immature Platelet Count (IPC) are better predictors of bleeding than the platelet count alone in neonates of different gestational and post-conceptional ages and with different etiologies of thrombocytopenia; and 2. To characterize the effects of neonatal thrombocytopenia and platelet transfusions (PLT Tx) on bleeding and on markers of systemic inflammation, thrombosis, and neutrophil extracellular traps (NET) formation in neonates with different underlying conditions.
CONDITIONS
Official Title
Impact of Thrombocytopenia and Platelet Transfusions on Neonatal Bleeding and Inflammation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a post-menstrual age between 23 and 44 weeks
- Have a platelet count less than 100 x 10^9/L
- Have a parent or guardian willing to provide written informed consent
You will not qualify if you...
- Not expected to survive for more than 5 days as assessed by the Attending Neonatologist
- Suspected congenital thrombocytopenia or platelet dysfunction based on family history or clinical signs
- Currently on extracorporeal membrane oxygenation (ECMO)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
2
Boston Children's Hospital
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
M
Martha Sola-Visner, MD
CONTACT
V
Vanessa J Young, RN, BA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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