Actively Recruiting
Impact of Tildrakizumab on Patient Reported Outcomes in Patients With Moderate-to-severe Psoriasis in Canada
Led by Chronicle Academy · Updated on 2026-01-27
80
Participants Needed
6
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multi-centre, non-interventional, open-label, prospective observational study that will be conducted across Canada over 52-week duration. Approximately 80 patients who are initiating tildrakizumab as part of their routine care through the ILUMYA SUPPORT® Program and meet the study's eligibility criteria will be enrolled. Specifically, the study will enroll patients with Fitzpatrick scale skin types III and above. The real-world impact, safety and effectiveness of tildrakizumab on patients with moderate-to-severe plaque psoriasis (PsO) remain largely undocumented in Canada, despite its approval in 2018. Given Canada's diverse population, this study presents an opportunity to evaluate tildrakizumab's quality of life, safety and effectiveness in specific demographic groups, particularly those patients with Fitzpatrick scale skin type III and above. The findings from this study will help optimize care, address unmet needs, and ensure that treatment outcomes are inclusive and reflective of Canada's diverse population.
CONDITIONS
Official Title
Impact of Tildrakizumab on Patient Reported Outcomes in Patients With Moderate-to-severe Psoriasis in Canada
Who Can Participate
Eligibility Criteria
You may qualify if you...
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Adults aged 18 years or older.
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Diagnosis of moderate-to-severe chronic plaque-type PsO with Fitzpatrick scale type III or above (BSA >/=3%).
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Candidate for phototherapy and/or systemic therapy.
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Planning to initiate tildrakizumab as part of routine clinical care through the ILUMYA SUPPORT® Program for the treatment of plaque PsO but has not yet received their first dose.
a. Decision to treat with tildrakizumab must be made independently of and prior to study recruitment.
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Must be able to read, understand, and communicate in English.
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Must be willing to participate in the study and capable to provide informed consent
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Able to comply with all study procedures and attend all study visits
You will not qualify if you...
- Known hypersensitivity to tildrakizumab, its excipients, or components of the container, as outlined in the Product Monograph.
- Concurrently taking any oral medication for treatment of PsO (e.g. methotrexate, cyclosporin, acitretin)
- Diagnosis of only palmoplantar psoriasis
- Concurrent medical condition or significant comorbidities that, in the investigator's opinion, would prevent participation in the study or interfere with study assessments
- Women of childbearing potential who are pregnant, planning to become pregnant, or breastfeeding.
- Prior (within 30 days) or actively participating in other interventional clinical trial(s).
- Unable or unwilling to comply with study procedures including completing questionnaire.
- Any other condition that, in the opinion of the investigator, could create a hazard to the participant's safety, endanger the study procedures, or interfere with the interpretation of study results
AI-Screening
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Trial Site Locations
Total: 6 locations
1
Burlington Skin and Wellness
Burlington, Ontario, Canada, L7L 3E5
Actively Recruiting
2
Locke Dermatology
Hamilton, Ontario, Canada, L8P 4B4
Actively Recruiting
3
Panorama Dermatology Clinic
Kanata, Ontario, Canada, K2T 0N7
Actively Recruiting
4
Centricity Research London Victoria Multispecialty
London, Ontario, Canada, N6A 2C2
Actively Recruiting
5
Factor Dermatology
Ottawa, Ontario, Canada, K2A 3Z3
Actively Recruiting
6
Saskatoon Dermatology Centre
Saskatoon, Saskatchewan, Canada, S7T0G3
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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