Effects of Treating Severe Gum Disease on Inflammation of Artery Plaques in Adults 30 to 70 Years Old After a Heart Attack

What this Trial Is About

Researchers are evaluating the impact of treating severe periodontitis on inflammation in atherosclerotic plaques among adults aged 30 to 70 who have been hospitalized for an acute myocardial infarction AMI. This multicenter randomized clinical trial compares specialized periodontal therapy performed by periodontists against usual dental care by dental surgeons. The study is nested within the Frenchie registry and aims to understand how periodontal treatment affects vascular inflammation and heart-related outcomes. Participants who have severe periodontitis will be randomly assigned to one of two groups the intervention group receives periodontal treatment lasting up to 6 months with follow-up care including a maintenance visit at month 9, while the control group continues with usual dental care provided by their own dentist. Both groups will undergo FDG-PET scans at the start and after 12 months to assess inflammation in carotid atherosclerotic plaques. Additional clinical periodontal assessments and blood samples will also be taken during the study. Throughout the trial, participants will have detailed oral examinations, blood draws, and imaging at baseline and 12 months. The study measures include the effect of periodontal treatment on inflammatory activity, vascular inflammation, and related biomarkers. Follow-up visits help monitor oral health and treatment adherence. The total participation time spans about 12 months, including treatment and observation periods, with safety and inflammation outcomes carefully evaluated.

Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)