Effect of Transcutaneous Tibial Nerve Stimulation on Bladder Symptoms and Quality of Life in Adults with Multiple Sclerosis

What this Trial Is About

Researchers are investigating the effectiveness of transcutaneous tibial nerve stimulation TTNS, a non-invasive treatment, for managing bladder storage symptoms in people with multiple sclerosis MS. MS often leads to neurogenic lower urinary tract dysfunction, causing symptoms like urinary frequency and urgency that negatively affect quality of life. This study aims to compare TTNS with a sham treatment to provide strong evidence on its impact on bladder symptoms and quality of life for people with MS. Participants will be randomly assigned to either an active TTNS group or a sham TTNS group. The active group will receive electrical stimulation on the medial side of the foot targeting the tibial nerve, while the sham group will have stimulation on the lateral side of the foot away from the nerve. Both groups will undergo 18 sessions over 6 weeks, with stimulation three times per week for 30 minutes each session. The devices will be pre-programmed to deliver consistent stimulation parameters. During the study, participants will complete questionnaires and bladder diaries to monitor bladder symptoms, quality of life, and sleep quality at the start, at 6 weeks, and 6 months post-intervention. The primary outcomes include the International Consultation of Incontinence Questionnaire for Overactive Bladder and bladder diaries. Researchers will also evaluate participants perceptions of change. The total participation duration includes follow-up assessments to monitor lasting effects and safety.

Impact of TTNS on Bladder Symptoms Among People With MS, A RCT