Actively Recruiting

Phase Not Applicable
Age: 23Years - 45Years
All Genders
ID05477901

Mental Health and Bolsa Familia: Clinical Trial of Cash Transfer Effects on Child Brain, Behavior, and Mental Health

Led by New York State Psychiatric Institute · Updated on 2026-04-23

450

Participants Needed

2

Research Sites

30 weeks

Total Duration

On this page

Sponsors

N

New York State Psychiatric Institute

Lead Sponsor

N

National Institute of Mental Health (NIMH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to evaluate the effects of the Auxilio Brasil (AB) cash transfer program on child neurodevelopment and mental health in resource-limited families in Brazil. The study focuses on children aged 7 to 10 years and investigates whether increasing cash transfers can reduce childhood adversities and improve brain function and behavior related to executive functions. The trial also explores how these cash transfers affect inflammatory markers and stress hormone activity, as well as whether these effects vary by the child's sex or gender and persist after the intervention ends. Participants are families already receiving AB cash transfers. The study randomly assigns 300 families to receive either a high supplemental cash transfer of $40 per month or a low supplemental transfer of $2 per month for two years. Up to 150 siblings aged 7 to 10 may also be included. The intervention builds on Brazil's existing national program, aiming to lift families out of poverty and study the resulting effects on children's brain and behavior. Assessments occur at baseline, about 8 and 16 months, at 24 months, and approximately 6 months after the trial ends. Throughout the study, researchers will collect data using brain MRI scans, executive function tests, blood and hair samples for inflammation and cortisol levels, family environment evaluations, and questionnaires about childhood adversity and mental health symptoms. These measures will be taken multiple times to track changes over the two-year period and post-trial. The study's goal is to understand the pathways by which cash transfers might protect children's development and mental health, providing valuable information for refining social assistance programs.

CONDITIONS

Brief Title

Impacts of Cash Transfers on Child Neurodevelopment (Auxilio Brasil)

Who Can Participate

Age: 23Years - 45Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Mothers aged 23 to 45 years old
  • Currently receiving Auxilio Brasil cash transfers
  • Have at least two children aged 7 to 10 years at recruitment (up to four children per family)
  • Able to provide consent
  • Children aged 7 to 10 years old
  • Children able to provide assent
Not Eligible

You will not qualify if you...

  • Mother and child do not live in the same household
  • Child has major psychiatric disorders such as Autism, Schizophrenia, or Bipolar disorder
  • Child has severe disability
  • Child has MRI contraindications (index child only)

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 24 months

Participants receive either high or low supplemental cash transfers monthly as part of the trial to assess impacts on child neurodevelopment and related outcomes.

Assessments at Baseline, 8 months, 16 months, and 24 months

Follow-up

Duration - 6 months post-treatment

Participants are monitored for continued effects on child neurodevelopment and wellbeing after the treatment phase ends.

1 follow-up assessment

Trial Site Locations

Total: 2 locations

1

New York State Psychiatric Institute

New York, New York, United States, 10032

Not Yet Recruiting

2

UNIFESP

São Paulo, São Paulo, Brazil, 04023

Actively Recruiting

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Research Team

C

Cristiane Duarte, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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