Actively Recruiting
The Impacts of Gluten-free Diet in Patients With Ankylosing Spondylitis
Led by Saglik Bilimleri Universitesi · Updated on 2025-09-10
60
Participants Needed
4
Research Sites
69 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Subclinical intestinal inflammation and intestinal permeability have been reported in patients with ankylosing spondylitis. Gluten is one of the main triggers of zonulin releaseand gluten intake may contribute to the development of the disease by increasing intestinal permeability. This study aims to determine the impacts of a gluten-freediet on intestinal permeability, sub-clinical intestinal inflammation, disease activity, functional status and quality of life in patients with ankylosing spondylitis. The main questions it aims to answer are: Does a gluten-free diet have an effect on disease activity and functional status in patients with ankylosing spondylitis? Does a gluten-free diet have an effect on intestinal permeability and subclinical intestinal inflammation in patients with ankylosing spondylitis? The investigators will evaluate the effects of the gluten-free diet compared to a control group.
CONDITIONS
Official Title
The Impacts of Gluten-free Diet in Patients With Ankylosing Spondylitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of axial spondyloarthritis defined by ASAS criteria
- Adults aged 18 to 64 years
- Stable treatment with NSAIDs and/or DMARDs for at least 3 months
- Provided written informed consent and agree to study requirements
You will not qualify if you...
- Following any diet currently or within 3 months prior to inclusion
- History of celiac disease
- History of Ulcerative Colitis, Crohn's Disease, or Irritable Bowel Syndrome
- Diagnosis of Type 1 or Type 2 Diabetes Mellitus
- Diagnosis of Hashimoto Thyroiditis
- Pregnant or breastfeeding
- Regular use of omega-3 or vitamins A, C, or E in the past 3 months
- Body mass index (BMI) less than 18.50 kg/m2
- Body mass index (BMI) 29.99 kg/m2 or higher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Bakırköy Dr. Sadi Konuk Training and Research hospital
Istanbul, Turkey (Türkiye)
Actively Recruiting
2
İstanbul Medeniyet University
Istanbul, Turkey (Türkiye)
Active, Not Recruiting
3
İstanbul Sağlık Bilimleri University
Istanbul, Turkey (Türkiye)
Active, Not Recruiting
4
Marmara University
Istanbul, Turkey (Türkiye)
Active, Not Recruiting
Research Team
G
Gülay Sezgin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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