Actively Recruiting
Imperial Prostate 7 - Prostate Assessment Using Comparative Interventions - Fast Mri and Image-fusion for Cancer
Led by Imperial College London · Updated on 2025-07-24
3600
Participants Needed
15
Research Sites
169 weeks
Total Duration
On this page
Sponsors
I
Imperial College London
Lead Sponsor
C
Cancer Research UK
Collaborating Sponsor
AI-Summary
What this Trial Is About
To evaluate the role of biparametric MRI and image-fusion targeted biopsies for the detection of prostate cancer. To determine whether biparametric MRI (bpMRI) could be recommended as an alternative to multiparametric MRI (mpMRI) for the detection of clinically significant prostate cancers in patients at risk. To determine whether image-fusion targeted biopsy is better than visual-registration (cognitive) targeted biopsy at detecting clinically significant prostate cancers in patients requiring prostate biopsy due to a suspicious MRI.
CONDITIONS
Official Title
Imperial Prostate 7 - Prostate Assessment Using Comparative Interventions - Fast Mri and Image-fusion for Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or above (no upper limit)
- Male patients with a prostate (cis-male or trans-female with no prior androgen deprivation hormone use)
- Referred for prostate MRI due to abnormal digital rectal exam and/or elevated PSA within 6 months
- PSA thresholds:
- 5B3 3.0ng/ml for ages 50-69
- 5B3 5.0ng/ml for age 5B3 70
- 5B3 2.5ng/ml for ages 45-49 with family or ethnic risk
- Visible suspicious finding on mpMRI or bpMRI requiring targeted biopsy (MRI score 3, 4, or 5)
You will not qualify if you...
- PSA > 50ng/ml
- Prior prostate MRI or biopsy within 2 years
- Previous diagnosis of prostate cancer
- Contraindication to MRI or gadolinium contrast
- Previous hip replacement in both hips
- Contraindication to biopsy guided by transrectal ultrasound
- Patient refusal for biopsy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
Southend University Hospital
Southend-on-Sea, Essex, United Kingdom, SS0 0RY
Actively Recruiting
2
University Hospital Southampton
Southampton, Hampshire, United Kingdom, SO16 6YD
Actively Recruiting
3
Medway Maritime Hospital
Gillingham, Kent, United Kingdom, ME7 5NY
Not Yet Recruiting
4
Basingstoke Hospital
Basingstoke, United Kingdom, RG24 9NA
Actively Recruiting
5
Southmead Hospital
Bristol, United Kingdom, BS10 5NB
Actively Recruiting
6
Addenbrooke Hospital, Cambridge
Cambridge, United Kingdom
Actively Recruiting
7
Cumberland Infirmary
Carlisle, United Kingdom, CA2 7HY
Actively Recruiting
8
St Peters Hospital
Chertsey, United Kingdom
Actively Recruiting
9
Darent valley Hospital
Dartford, United Kingdom, DA2 8DA
Actively Recruiting
10
Northwick Park Hospital
Harrow, United Kingdom
Actively Recruiting
11
St James's Hospital, Leeds
Leeds, United Kingdom
Actively Recruiting
12
Charing Cross Hospial
London, United Kingdom, W6 8RF
Actively Recruiting
13
Manchester Royal Infirmary
Manchester, United Kingdom
Actively Recruiting
14
Northampton General Hospital
Northampton, United Kingdom
Actively Recruiting
15
Hillingdon Hospital
Uxbridge, United Kingdom, UB8 3NN
Actively Recruiting
Research Team
H
Hashim Ahmed
CONTACT
T
Thiagarajah Sasikaran
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
4
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