Using an Implantable Cardiac Monitor to Detect Atrial Fibrillation in Adults with MINOCA A 5-Year Study on Causes and Outcomes of MINOCA with and without Cardiac Monitor

What this Trial Is About

Researchers are studying myocardial infarction with non-obstructive coronary arteries MINOCA, a condition affecting about 5-6% of patients with acute myocardial infarction. Many patients with MINOCA remain without a proper diagnosis or treatment. This study aims to systematically identify underlying causes of MINOCA and track patient outcomes over five years, including the use of an implantable cardiac monitor ICM to detect atrial fibrillation as a potential cause of MINOCA. Participants are divided into two groups those eligible for ICM implantation and those ineligible due to refusal, contraindications, or a known cause of MINOCA. The ICM group will receive the CONFIRM Rx implantable cardiac rhythm monitor, while both groups undergo a thorough diagnostic work-up including imaging and tests such as intracoronary optical coherence tomography, cardiac magnetic resonance imaging, transesophageal echocardiography, vasospasm testing, thrombophilia screening, and Holter ECG non-ICM group only. During the study, participants will be closely monitored for occurrences of atrial fibrillation and other cardiac events through the ICM and diagnostic tests. Researchers will assess outcomes including time to atrial fibrillation diagnosis, atrial fibrillation burden, stroke, death, and other arrhythmias over several years. Clinical outcomes will be followed for five years to better understand MINOCA causes and patient health. The study includes regular evaluations and data collection to support comprehensive long-term monitoring.

Implantable Cardiac Monitor to Detect Atrial Fibrillation in Patients With MINOCA