Actively Recruiting
Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death
Led by Kee-joon Choi · Updated on 2025-06-15
140
Participants Needed
25
Research Sites
756 weeks
Total Duration
On this page
Sponsors
K
Kee-joon Choi
Lead Sponsor
C
CardioVascular Research Foundation, Korea
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to determine whether ICD(Implantable Cardioverter Defibrillator) implantation on the top of optimal medical therapy in patients with variant angina manifesting as aborted sudden cardiac death reduces the incidence of the death from any cause compared with optimal medical therapy alone.
CONDITIONS
Official Title
Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Patients who had a successfully resuscitated cardiac arrest due to documented ventricular fibrillation or sustained rapid ventricular tachycardia
- Diagnosed with variant angina confirmed by spontaneous coronary spasm with ST elevation (≥0.1mV) in coronary angiogram and/or documented coronary spasm on ergonovine provocation coronary angiography
You will not qualify if you...
- Significant coronary artery stenosis greater than 50% on coronary angiography
- Known organic heart disease linked to sudden cardiac arrest, including heart failure with left ventricular ejection fraction below 35%, left ventricular akinesia or aneurysm, hypertrophic cardiomyopathy, and arrhythmogenic right ventricular dysplasia
- Chronic heart failure classified as New York Heart Association functional class III or IV
- Prior history of atrial or ventricular arrhythmia requiring class I or III antiarrhythmic drugs (flecainide, propafenone, amiodarone, sotalol, dronedarone)
- Previous catheter ablation for ventricular arrhythmia
- Primary cardiac electrical diseases like long QT syndrome, Brugada syndrome, or catecholaminergic polymorphic ventricular tachycardia
- Previous pacemaker or Implantable Cardioverter Defibrillator
- Second or third degree AV block not related to coronary ischemia requiring a permanent pacemaker
- Poor neurologic outcome defined as cerebral performance category scale 3 or higher
- Life expectancy less than 2 years
- Psychiatric illnesses that could worsen with device implantation or prevent follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 25 locations
1
Soon Chun Hyang University Hospital Bucheon
Bucheon-si, South Korea
Actively Recruiting
2
Busan National University Yangsan Hospital
Busan, South Korea
Actively Recruiting
3
Busan University Hospital
Busan, South Korea
Actively Recruiting
4
Dong-A Medical Center
Busan, South Korea
Actively Recruiting
5
Soon Chun Hyang University Hospital Cheonan
Cheonan, South Korea
Actively Recruiting
6
Keimyung University Dongsan Medical Center
Daegu, South Korea
Actively Recruiting
7
Chungnam National University Hospital
Daejeon, South Korea
Actively Recruiting
8
Gangneung Asan Hospital
Gangneung, South Korea
Withdrawn
9
Chonnam National University Hospital
Gwangju, South Korea
Actively Recruiting
10
Wonkwang University Hospital
Iksan, South Korea
Withdrawn
11
Gachon University Gil Medical Center
Incheon, South Korea
Actively Recruiting
12
Chonbuk National University Hospital
Jeonju, South Korea
Actively Recruiting
13
Chungnam National University Sejong Hospital
Sejong, South Korea
Actively Recruiting
14
Seoul university Bundang hospital
Seongnam, South Korea
Actively Recruiting
15
Asan Medical Center
Seoul, South Korea
Actively Recruiting
16
Ewha Womans University Mokdong Hospital
Seoul, South Korea
Actively Recruiting
17
Kangdong KyungHee University hospital
Seoul, South Korea
Actively Recruiting
18
Korea University Anam Hospital
Seoul, South Korea
Actively Recruiting
19
Korea University Guro Hospital
Seoul, South Korea
Terminated
20
Seoul National University Boramae Medical Center
Seoul, South Korea
Actively Recruiting
21
Seoul National University Hospital
Seoul, South Korea
Actively Recruiting
22
Severance Hospital
Seoul, South Korea
Withdrawn
23
The Catholic Univ. of Korea, Seoul St. Mary's Hospital
Seoul, South Korea
Actively Recruiting
24
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
Seoul, South Korea
Withdrawn
25
Ajou University Hospital
Suwon, South Korea
Active, Not Recruiting
Research Team
K
Kee-joon Choi, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here