Actively Recruiting
Integrated Model for the Prevention of Anal Cancer Using Screen and Treat for High-grade Intraepithelial Lesions (IMPACT)
Led by University of Maryland, Baltimore · Updated on 2025-06-26
1
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Maryland, Baltimore
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating two different training protocols for a physician to improve anal cancer screening and treatment in Nigeria. The study focuses on high-grade intraepithelial lesions (HSILs), which are precancerous changes that can lead to anal cancer, aiming to compare the current standard training developed in high-income countries with a new training tailored specifically for the Nigerian setting. This pilot trial assesses whether the physician's ability to perform screening and treatment differs between the two training approaches. The study first applies the standard training for 12 months, then develops and rolls out an enhanced training intervention (e-STH) tailored to address barriers unique to Nigeria over a 6-month period. After this, there is a 12-month post-intervention period to evaluate the impact of the enhanced training, followed by a 6-month sustainability phase with minimal study team involvement. The enhanced training is refined iteratively by an implementation science committee to promote adoption and maintenance of HSIL screening and treatment. During the trial, the physician's performance in detecting and treating HSIL will be monitored continuously. Researchers will assess outcomes including changes in detection and treatment rates, reach and efficacy of screening, implementation success, and maintenance of the program. The study uses an interrupted time series design at a single clinic to minimize variability and will involve regular monitoring over a total period of about 3 years.
CONDITIONS
Brief Title
Implementation of Anal Cancer Screening and Treatment in Nigeria
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Possess a medical degree in medical sciences (MBBS or equivalent)
- Have at least 2 to 5 years of experience working with the clinical HIV/AIDS community
- Be registered with the medical and dental council of Nigeria
- Possess a current medical practicing license
- Be willing to work with the Sexual Gender Minority Community
You will not qualify if you...
- None listed
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Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 months
Participants undergo standard training and perform HSIL screening and treatment as outlined by the International Anal Neoplasia Society to establish baseline practices.
Ongoing clinical activities as part of routine care
Duration - 6 months
Participants receive tailored enhanced training on HSIL screening and treatment designed to overcome barriers and improve implementation, developed over iterative cycles.
Training sessions spread over the implementation period
Duration - 12 months
Participants continue HSIL screening and treatment following enhanced training to evaluate the impact of the new training model.
Ongoing clinical activities as part of routine care
Duration - 6 months
Participants perform HSIL screening and treatment with minimal involvement from the investigative team to assess sustainability of the enhanced training effects.
Ongoing clinical activities as part of routine care
Trial Site Locations
Total: 1 location
1
International Center for Advocacy on Right to Health (ICARH)
Abuja, Nigeria
Actively Recruiting
Research Team
R
Rebecca Nowak, PhD
S
Sylvia Adebajo
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
PREVENTION
Number of Arms
2
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