Actively Recruiting
Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)
Led by The University of Queensland · Updated on 2026-03-31
1174
Participants Needed
49
Research Sites
417 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will investigate if a medication (metformin) widely used in the treatment of diabetes could be re-purposed for the treatment of patients with a diagnosis of early stage ADPKD to slow the rate of kidney function decline, reducing morbidity and mortality and improving the quality of life for ADPKD patients.
CONDITIONS
Official Title
Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing to participate and provide informed consent
- Aged 18-70 years
- Diagnosis of ADPKD based on radiological or genetic criteria as per Kidney Health Australia guidelines
- eGFR equal to or greater than 38 mL/min/1.73m2 and less than 90 mL/min/1.73m2
- Have one or more risk factors of progression such as bilateral kidney length ≥16.5 cm, total kidney volume ≥750 mL, height-adjusted total kidney volume ≥600 mL/m2, Mayo class IC/D/E, or Pro-PKD score ≥6
- Or evidence of active progression shown by decline in eGFR ≥5 mL/min/1.73m2 in one year, or decline in eGFR ≥3 mL/min/1.73m2 per year over five or more years, or increase in kidney volume ≥5% per year on at least two measurements in the past year with specific conditions for those on tolvaptan therapy
You will not qualify if you...
- Diagnosis of diabetes mellitus or other systemic conditions causing chronic kidney disease independent of PKD (excluding hypertension)
- Uncontrolled hypertension with systolic blood pressure >160 mmHg or diastolic blood pressure >100 mmHg after rest
- Clinically significant heart failure classified as New York Heart Association Class III or IV
- Non-polycystic liver disease with liver enzymes more than twice the normal limit or Child-Pugh score ≥5
- Contraindications to metformin including abnormal liver function tests or untreated Vitamin B12 deficiency
- Currently taking metformin
- Pregnant, breastfeeding, or planning pregnancy within three years
- Comorbidities that may affect trial outcomes including active cancer, history of solid organ transplants, active COPD, active inflammatory bowel disease, or presence of a stoma
- History of dialysis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 49 locations
1
Renal Research
Gosford, New South Wales, Australia, 2250
Active, Not Recruiting
2
Royal Prince Alfred Hospital
Sydney, New South Wales, Australia, 2050
Active, Not Recruiting
3
Royal North Shore Hospital
Sydney, New South Wales, Australia, 2065
Active, Not Recruiting
4
Westmead Hospital - Western Sydney Local Health District
Sydney, New South Wales, Australia, 2145
Active, Not Recruiting
5
Bundaberg Hospital
Bundaberg, Queensland, Australia, 4670
Active, Not Recruiting
6
Townsville University Hospital
Douglas, Queensland, Australia, 4814
Active, Not Recruiting
7
Royal Brisbane and Women's Hospital
Herston, Queensland, Australia, 4006
Active, Not Recruiting
8
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia, 4102
Active, Not Recruiting
9
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
Active, Not Recruiting
10
Royal Melbourne Hospital
Melbourne, Victoria, Australia, 3052
Active, Not Recruiting
11
Austin Health
Melbourne, Victoria, Australia, 3084
Active, Not Recruiting
12
Monash Medical Centre
Melbourne, Victoria, Australia, 3168
Active, Not Recruiting
13
Sir Charles Gairdner Hospital
Perth, Western Australia, Australia, 6009
Active, Not Recruiting
14
Te Whatu Ora - Hauora a Toi Bay of Plenty
Tauranga, Bay of Plenty, New Zealand, 3112
Actively Recruiting
15
Te Whatu Ora - Te Tai Tokerau
Whangārei, Northland, New Zealand, 0110
Actively Recruiting
16
Te Whatu Ora - Southern
Dunedin, Otago, New Zealand, 9016
Actively Recruiting
17
Te Whatu Ora - Taranaki
New Plymouth, Taranaki Region, New Zealand, 4310
Actively Recruiting
18
Ta Pae Hauora o Ruhahine o Terarua Mid Central
Palmerston North, New Zealand
Actively Recruiting
19
Royal Devon & Exeter Hospital
Exeter, Devon, United Kingdom, EX2 5DW
Actively Recruiting
20
Nottingham Renal Unit, Nottingham City Hospital
Nottingham, East Midlands, United Kingdom, NG5 1PB
Not Yet Recruiting
21
Raigmore Hospital
Inverness, Inverness Shire, United Kingdom, IV2 3UJ
Not Yet Recruiting
22
Royal Preston Hospital
Preston, Lancashire, United Kingdom, PR2 9HT
Not Yet Recruiting
23
Salford Royal Hospital
Salford, Lancashire, United Kingdom, M6 8HD
Actively Recruiting
24
Leicester General Hospital
Leicester, Leicestershire, United Kingdom, LE5 4PW
Actively Recruiting
25
St Helier Hospital
Carshalton, London, United Kingdom, SM5 1AA
Not Yet Recruiting
26
Aintree University Hospital
Liverpool, Merseyside, United Kingdom, L9 7AL
Actively Recruiting
27
Norfolk and Norwich University Hospital
Norwich, Norfolk, United Kingdom, NR4 7UY
Not Yet Recruiting
28
Antrim Area Hospital
Antrim, Northern Ireland, United Kingdom, BT41 2RL
Actively Recruiting
29
Ulster Hospital
Belfast, Northern Ireland, United Kingdom, BT16 1RH
Actively Recruiting
30
Altnagelvin Hospital
Londonderry, Northern Ireland, United Kingdom, BT47 6SB
Actively Recruiting
31
Daisy Hill Hospital
Newry, Northern Ireland, United Kingdom, BT35 8DR
Not Yet Recruiting
32
Oxford Kidney Unit, Churchill Hospital,
Oxford, Oxfordshire, United Kingdom, OX3 7LE
Actively Recruiting
33
Doncaster Royal Infirmary
Doncaster, South Yorkshire, United Kingdom, DN2 5LT
Actively Recruiting
34
Sheffield Kidney Institute
Sheffield, South Yorkshire, United Kingdom, S5 7AU
Actively Recruiting
35
Royal Stoke University Hospital
Stoke-on-Trent, Staffordshire, United Kingdom, ST4 6QG
Not Yet Recruiting
36
Freeman Hospital
Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE7 7DN
Not Yet Recruiting
37
Queen Elizabeth Hospital Birmingham
Birmingham, West Midlands, United Kingdom, B15 2GW
Not Yet Recruiting
38
Bradford Renal Unit, St Luke's Hospital
Bradford, West Yorkshire, United Kingdom, BD5 0NA
Actively Recruiting
39
Cardiff and Vale University Health Board
Cardiff, United Kingdom
Actively Recruiting
40
Epsom and St Helier University Hospitals
Carshalton, United Kingdom
Actively Recruiting
41
The Royal London Hospital
London, United Kingdom, E1 1FR
Not Yet Recruiting
42
Royal Free Hospital
London, United Kingdom, NW3 2QG
Not Yet Recruiting
43
King's College Hospital
London, United Kingdom, SE5 9RS
Not Yet Recruiting
44
St George's University Hospital
London, United Kingdom
Actively Recruiting
45
Nottingham University Hospital
Nottingham, United Kingdom
Actively Recruiting
46
University Hospitals Plymouth NHS Trust
Plymouth, United Kingdom
Actively Recruiting
47
East & North Hertfordshire Teaching NHS Trust
Stevenage, United Kingdom
Actively Recruiting
48
South Tyneside and Sunderland NHS Foundation Trust
Sunderland, United Kingdom
Actively Recruiting
49
York and Scarborough Teacehing Hospitals
York, United Kingdom
Actively Recruiting
Research Team
M
Misa Matsuyama, PhD
CONTACT
P
Pushparaj Velayudham
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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