Actively Recruiting

Age: 18Years +
All Genders
NCT07268066

Implementation of the Methylome in the Characterization of Solid Tumors

Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-12-18

180

Participants Needed

1

Research Sites

136 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study aims to investigate the functional consequences of specific methylation changes and to examine the clinical implications of these alterations. Methylation analysis is a powerful tool for understanding the molecular mechanisms of brain tumors and other solid tumors and can help identify new diagnostic and therapeutic targets. By analyzing DNA methylation patterns in tumor tissue, it is possible to identify genes that are silenced or activated by methylation. This information can be used to develop new biomarkers for early diagnosis and to identify new therapeutic targets that can be used to reverse methylation-mediated gene silencing.

CONDITIONS

Official Title

Implementation of the Methylome in the Characterization of Solid Tumors

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Confirmed diagnosis of gliomas, malignant thyroid neoplasms, or endometrial carcinomas according to WHO Nomenclature
  • Availability of adequate tumor tissue material for analysis, specifically at least 3 sections of 10 m of FFPE
Not Eligible

You will not qualify if you...

  • No exclusion criteria specified

AI-Screening

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Trial Site Locations

Total: 1 location

1

IRCCS Azienda Ospedaliero Univesitaria di Bologna

Bologna, BO, Italy, 40138

Actively Recruiting

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Research Team

G

Giovanni Tallini, Prof.

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Implementation of the Methylome in the Characterization of Solid Tumors | DecenTrialz