Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates.
Mark S Gold, Firas H Kobeissy, Kevin K W Wang...
https://pubmed.ncbi.nlm.nih.gov/19345341/Actively Recruiting
Led by Queen's Medical Center · Updated on 2026-03-31
40
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying contingency management CM as a behavioral approach to address methamphetamine use among individuals in Hawaii who have been hospitalized due to traumatic injury. The study aims to gather data on the effectiveness of a pilot CM program and to understand participant perspectives on engaging with this intervention at a Level 1 Trauma Center. This research focuses on both patient-reported and biologically-confirmed outcomes over the medium term. Participants will attend follow-up clinics up to three times per week for up to 12 weeks after discharge to complete urinalysis tests. Those who test negative for methamphetamine receive positive reinforcement through a prize draw with various rewards ranging from praise to valuable items. The program includes Treatment Effectiveness Assessments at 6 and 12 weeks, along with a qualitative interview conducted at the end of the CM program. Throughout the study, participants will provide urine samples multiple times weekly and complete scheduled assessments to measure treatment effectiveness. The primary outcomes include the Treatment Effectiveness Assessment results at 6 and 12 weeks, and qualitative feedback is collected at the programs conclusion. The total participation period covers enrollment through 12 weeks post-discharge, with ongoing encouragement to continue engagement regardless of test results.
CONDITIONS
Implementing a Contingency Management Program Addressing Methamphetamine Use For and With the People of Hawaii
N
Nicholas R Schumann, Clinical Psychologist
K
Karen Ng, RN
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Queen's Medical Center
Lead Sponsor
National Institute of General Medical Sciences (NIGMS)
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Contingency Management Behavioral Program (trial intervention) | Usual Care (no structured contingency management) |
|---|---|---|
| What is it? | A behavioral intervention where hospitalized trauma patients with methamphetamine use disorder receive incentives, such as praise or prize slips, contingent on providing methamphetamine-negative urine tests. Incentives range from praise to gift cards or other rewards. | Patients typically receive standard medical care and may be offered counseling or referrals for substance use, but structured contingency management with incentives is not routinely used in most current settings for stimulant use disorder. |
| Role in the trial | This is the sole intervention studied in the single-arm trial for eligible patients during hospital admission and early recovery. | Serves as the contemporary care outside the context of the trial—no formal incentives or contingency management; care may include supportive counseling or referral, but not structured behavioral rewards. |
| Primary use or aim | To reinforce and encourage abstinence from methamphetamine use among trauma patients during and after hospitalization through behavioral incentives linked to drug-negative urine screens. | To provide general support, counseling, or referral services to patients with methamphetamine use disorder, without incentive-based reinforcement of abstinence. |
| How is it given or performed? | Participants provide urine samples during the hospital stay and at follow-up visits; each methamphetamine-negative sample leads to a draw for incentives immediately on-site. | No structured onsite reinforcement or incentive-based system. Patients may receive advice, counseling, or referral to addiction services, depending on standard institutional practice. |
| Evidence status | Contingency management has demonstrated effectiveness for stimulant use disorder in systematic reviews, but further real-world implementation evidence—including hospital trauma populations—remains limited and is the focus of ongoing research in this trial. | Usual care alone is associated with lower rates of sustained abstinence and higher relapse risk compared to contingency management, as incentive-based methods are not included. |
| Important limitations | Sustained effectiveness for methamphetamine abstinence has mostly been shown in research settings rather than routine clinical practice, and there may be logistical or institutional barriers to program delivery in real-world trauma care. | Usual care without structured incentives is less likely to lead to sustained abstinence from methamphetamine and does not actively reinforce drug-negative behavior; relapse and ongoing use are more common without contingency management. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 12 weeks
Participants complete Contingency Management sessions three times per week for up to 12 weeks, receiving incentives for methamphetamine-negative samples and encouragement to continue participation if positive.
Three visits per week for up to 12 weeks
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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https://pubmed.ncbi.nlm.nih.gov/32555667/Queen's Medical Center
Lead Sponsor
National Institute of General Medical Sciences (NIGMS)
Collaborating Sponsor