Actively Recruiting
Implementing Depression and Adherence Treatment
Led by University of Miami · Updated on 2026-04-03
10
Participants Needed
3
Research Sites
212 weeks
Total Duration
On this page
Sponsors
U
University of Miami
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare a core set and enhanced set of implementation strategies in increasing the reach of evidence-based treatments to patients with HIV and depression. The main questions it aims to answer are: What proportion of patients start an evidence-based treatment for depression (reach)? What percentage of patients show clinical improvement in depression and what percentage attain viral undetectability within one year (effectiveness)? Researchers will compare high and low reach clinics to further inform tailored implementation strategies for uptake and maintenance. Clinics will be randomized into one of two study arms: core versus enhanced strategies. In both arms, core strategies will be utilized. Enhanced clinics will also receive more resource-intensive training.
CONDITIONS
Official Title
Implementing Depression and Adherence Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinics provide HIV primary care through the City of Cape Town Department of Health
- Clinics assigned to the study before startup
- Patients aged 18 years or older
- Patients have a detectable or presumed detectable HIV viral load
- Patients screen positive for depression via the PHQ
You will not qualify if you...
- Children under 18 years of age are not included
AI-Screening
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Trial Site Locations
Total: 3 locations
1
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
2
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
3
University of Cape Town
Cape Town, South Africa
Actively Recruiting
Research Team
S
Steven A Safren, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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