Actively Recruiting
Implications of Myelin in Executive Control in Adolescence and Early Adulthood
Led by Centre Hospitalier St Anne · Updated on 2025-09-02
128
Participants Needed
1
Research Sites
207 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The Myelex study is a fundamental research study that aims to better understand how the brain functions and develops. The objective of this study is to better understand the role of myelin, a sheath that surrounds nerve fibers and determines the speed of information propagation in the brain, in cognitive functioning during development in adolescents and young adults. investigator use Magnetic Resonance Imaging (MRI) because this method allows us to study the anatomy and functioning of the brain in a non-invasive (no injection) and painless manner. investigator focus on cognitive control, a set of cognitive functions in the prefrontal cortex, at the front of the brain, that enable the use of the best strategies on a case-by-case basis to solve problems effectively. These functions are closely associated with academic and professional success and develop late, continuing until early adulthood. The goal of this project is simple: to measure the myelin of nerve fibers using MRI and to evaluate the link with the development of cognitive control. Each participant will undergo an MRI examination and cognitive assessments. The study takes place at the Clinical Research Center of GHU Paris and lasts a total of 3.5 hours, including reception, setup, MRI recording, and the completion of a series of cognitive tasks.
CONDITIONS
Official Title
Implications of Myelin in Executive Control in Adolescence and Early Adulthood
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 10 to 25 years
- Right-handed preference
- Participant or legal representative has given informed consent
- Native French speaker
- Affiliated with a social security system
- For minors, consent from at least one parent (justified if only one parent consents)
You will not qualify if you...
- Outside the age range of 10 to 25 years
- Contraindications to MRI (including pacemaker, cochlear implants, metal prostheses, claustrophobia, pregnancy, and others)
- Chronic alcohol or drug use
- Substance abuse or dependence (except nicotine) lasting over 5 years or causing coma
- Sudden cognitive disorders suggesting stroke or significant head trauma
- Chronic neurological, psychiatric, endocrine, liver, or infectious diseases
- History of major illnesses like diabetes, severe cardiac, metabolic, or cancer
- Use of medications that interfere with brain imaging (psychotropics, neuroleptics, etc.)
- Color blindness
- Inability to comply due to geographic or psychiatric reasons
- Tattoos incompatible with MRI
- Cerebral palsy
- Fine motor skill disorders
- Pregnant at time of inclusion
- Adults under legal protection or unable to consent
- Children or parents under legal protection measures
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
GHU Ste Anne
Paris, France, 75013
Actively Recruiting
Research Team
A
Arnaud Cachia
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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