Actively Recruiting
The Importance of Non-essential Amino Acids for Maintaining Skeletal Muscle Protein Synthesis Rates in Healthy Young Men
Led by Maastricht University Medical Center · Updated on 2024-12-24
64
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Protein intake is important for maintaining skeletal muscle mass. These proteins consist of a collection of small building blocks which are called amino acids. There are two types of amino acids that are needed to build muscle: essential amino acids (EAA) and non-essential amino acids (NEAA). EAAs cannot be made in the body and must be consumed through foods, while NEAAs can be made within the body. However, if NEAA are not consumed through foods, the process of making NEAA in the body costs the body energy. It is still unknown what the impact of a diet containing too few non-essential amino acids is for muscle building and the body's energy metabolism. Objective: To determine if a diet lacking NEAA, with or without being replaced by additional EAA, influences muscle protein building and whole-body metabolism. Study design: Randomized, parallel design, double-blind, 10-day dietary intervention study. Study population: 45 healthy (BMI 22-30 kg/m2) young males (age: 18-35 y inclusive). Hypothesis: It is hypothesized that a diet lacking NEAA, with or without being replaced by additional EAA, decreases muscle protein building in humans.
CONDITIONS
Official Title
The Importance of Non-essential Amino Acids for Maintaining Skeletal Muscle Protein Synthesis Rates in Healthy Young Men
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male
- Age between 18 and 35 years inclusive
- Body mass index (BMI) between 22 and 30 kg/m2
- Non-smoker
- Provided informed consent
You will not qualify if you...
- Participating in a structured (progressive) exercise program
- Smoker
- Diagnosed gastrointestinal tract disorders or diseases
- Diagnosed musculoskeletal disorders
- Diagnosed metabolic disorders such as diabetes
- Cardiovascular disease
- Hypertension with blood pressure above 140/90 mmHg
- Donated blood within 3 months prior to the test day
- Use of medications affecting protein metabolism like corticosteroids or non-steroidal anti-inflammatories
- Chronic use of gastric acid suppressing medications
- Chronic use of anti-coagulants
- Any intolerance to foods included in the standardized diet intervention
- Any implants contraindicating MRI scans
AI-Screening
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Trial Site Locations
Total: 1 location
1
Maastricht University Medical Center
Maastricht, Netherlands
Actively Recruiting
Research Team
H
Heather Petrick, MSc
CONTACT
L
Luc van Loon, Prof, Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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