Actively Recruiting
Improve the Strategies of Endoscopic and Interventional Treatment of Gastroesophageal Hemorrhage in Portal Hypertension: Novel Strategies for Diagnosis, Treatment and Prognostic Assessment System of Cirrhotic Portal Hypertension
Led by Shanghai Zhongshan Hospital · Updated on 2025-05-14
1450
Participants Needed
10
Research Sites
261 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are exploring new strategies to improve the treatment of esophagogastric varices in patients with cirrhosis and portal hypertension, conditions that cause dangerous bleeding. The study focuses on creating personalized treatment plans based on the unique vascular structures and blood flow patterns in each patient, aiming to reduce the high rate of rebleeding that currently occurs despite standard therapies. This observational study will help build models to better predict risks and tailor treatments for individuals. The study involves assessing patients' esophagogastric varices using advanced imaging techniques like portal venous CT and ultrasound, along with clinical data, to understand their vascular characteristics. Based on this information, researchers will develop and validate models to stratify patients and guide precise treatments, including endoscopic and interventional therapies. The study will enroll multiple patient groups to train and validate these models, and also investigate whether drugs that lower portal venous pressure, such as carvedilol or new oral anticoagulants, can reduce rebleeding risk in patients with poor outcomes. Participants will undergo imaging and endoscopic examinations to collect data on their varices and overall condition. Researchers will monitor gastrointestinal bleeding and other clinical events over periods ranging from six months to five years. The study aims to evaluate the safety and effectiveness of personalized treatment approaches and assess long-term outcomes, including the potential for reversing portal hypertension. Participants may be followed up for several years to gather comprehensive data on their health status and treatment responses.
CONDITIONS
Brief Title
Improve the Strategies of Endoscopic and Interventional Treatment of Gastroesophageal Hemorrhage in Portal Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of portal hypertension
- Underwent imaging and endoscopic examination or treatment within one week after admission
- Endoscopy revealed the presence of esophageal and/or gastric varices
You will not qualify if you...
- CT image slice thickness does not meet the requirements or there are artifacts
- Endoscopy shows no presence of esophageal and/or gastric varices
- Presence of severe life-threatening diseases of the circulatory, hematological, or respiratory systems
- Lack of important historical medical information or other relevant data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Within 1 week after admission
Participants undergo imaging and endoscopic examinations to evaluate esophageal and gastric varices related to portal hypertension.
1 to 2 visits depending on assessments
Duration - Up to 5 years
Participants are followed over several years to monitor gastrointestinal bleeding and other clinical events related to portal hypertension.
Periodic follow-up visits over 6 months, 1 year, 3 years, and 5 years
Trial Site Locations
Total: 10 locations
1
Southern Medical University Nanfang Hospital
Guangzhou, Guangdong, China
Actively Recruiting
2
The Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
Actively Recruiting
3
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
Actively Recruiting
4
People's Liberation Army Northern Theater General Hospital
Shenyang, Liaoning, China
Actively Recruiting
5
Qilu Hospital of Shandong University
Jinan, Shandong, China
Actively Recruiting
6
Shandong Provincial Hospital
Jinan, Shandong, China
Actively Recruiting
7
Renji Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200000
Actively Recruiting
8
Shanghai Changzheng Hospital
Shanghai, Shanghai Municipality, China, 200000
Actively Recruiting
9
Shanghai East Hospital
Shanghai, Shanghai Municipality, China, 200000
Actively Recruiting
10
Zhongshan Hospital
Shanghai, Shanghai Municipality, China, 200000
Actively Recruiting
Research Team
Y
Yiting Wang, Ph.D.
X
xiaoquan huang, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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