Actively Recruiting
Improved Diagnosis of Ovarian Cancer by Use of Circulating Tumor DNA as a Biomarker
Led by University of Aarhus · Updated on 2024-05-09
300
Participants Needed
1
Research Sites
357 weeks
Total Duration
On this page
Sponsors
U
University of Aarhus
Lead Sponsor
A
Aarhus University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This project investigates circulating tumor DNA (ctDNA) in patients with suspected ovarian malignancy. We hypothesize that measurement of ctDNA in women with suspected ovarian cancer can improve the diagnostic efficiency for preoperative differentiation between benign and malignant masses. Specifically, we hope to determine the diagnostic efficiency of ctDNA alone and ctDNA in combination with imaging modalities (ultrasonography, MRI, PET-CT) and CA 125 for preoperative differentiation between benign and malignant adnexal masses. Based on this, we hope to develop an improved diagnostic algorithm. The mutational profile and relation to tumour type, stage, treatment response and prognosis will be explored. Analyses of blood and tissue samples will be used to examine the disease development and biology. Blood samples, tumour tissue and data on imaging modalities as well as CA 125 will be collected prospectively in consecutive women referred to Aarhus University Hospital.
CONDITIONS
Official Title
Improved Diagnosis of Ovarian Cancer by Use of Circulating Tumor DNA as a Biomarker
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Suspected ovarian neoplasm
- Informed consent
You will not qualify if you...
- Inability to give informed consent
- Previous ovarian cancer diagnosis
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Gynaecology and Obstetrics, Aarhus University Hospital
Aarhus, Denmark
Actively Recruiting
Research Team
I
Ina Marie Dueholm Hjorth, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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