Actively Recruiting
Improved Hemodynamic Tolerance of Intermittent Hemodialysis Sessions in Intensive Care Unite Using Citrate- vs Acetate-based Dialysate
Led by Centre Hospitalier de Bethune · Updated on 2026-05-08
48
Participants Needed
5
Research Sites
186 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier de Bethune
Lead Sponsor
C
CHU de Lille
Collaborating Sponsor
AI-Summary
What this Trial Is About
During intermittent hemodialysis (IHD), the occurrence of intradialytic hemodynamic instability (IHI) is frequent in ICU and impacted morbidity and mortality. Bicarbonate dialysate buffer improves hemodynamic tolerance compared to acetate dialysate buffer. However, bicarbonate dialysate buffer still contains a lower concentration of acetate, which could contribute to hemodynamic instability. Recently, citrate-based dialysate in bicarbonate hemodialysis instead of acetate have been proposed. They have the appropriate authorizations for routine use. The aim of this study is to compare acetate- vs citrate-based dialysate in terms of hemodynamic tolerance and effectiveness.
CONDITIONS
Official Title
Improved Hemodynamic Tolerance of Intermittent Hemodialysis Sessions in Intensive Care Unite Using Citrate- vs Acetate-based Dialysate
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient 63 18 years old
- Patient hospitalized in an intensive care unit
- Patient with acute renal failure defined by a KDIGO stage 63 1 and suspected non-obstructive
- Patient at risk of per dialytic hypotension (capillary refill time 63 3 seconds and/or cardiovascular SOFA 63 1 and/or lactatemia > 2mmol/L)
- Indication for Extra Renal Replacement Therapy with IHD.
You will not qualify if you...
- Pregnant or breastfeeding woman
- Known chronic renal insufficiency of any stage
- Cardio-renal and hepato renal syndrome
- Unstable hemodynamic state: refractory shock
- Patient included in another interventional study likely to modify the hemodynamic state
- Patient deprived of liberty
- Patient under guardianship or curatorship
- Patient not affiliated to a social security system
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Centre Hospitalier Béthune
Béthune, France, 62408
Actively Recruiting
2
CHU
Caen, France
Actively Recruiting
3
Centre Hospitalier Universitaire de Dijon
Dijon, France
Actively Recruiting
4
CHRU Nancy
Nancy, France
Actively Recruiting
5
CHU de ROUEN
Rouen, France, 59507
Not Yet Recruiting
Research Team
M
Martin GÉRARD
CONTACT
C
Christophe VINSONNEAU
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here