Actively Recruiting
Improvement of Memory in Mild Cognitive Impairment
Led by Lucie Bréchet · Updated on 2025-07-15
40
Participants Needed
1
Research Sites
252 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The Clinical Trial will systematically examine the feasibility of remote, caregiver-led tACS for older adults with memory deficits and evaluate whether repeated tACS leads to sustained improvement of neuronal activity and memory functions.
CONDITIONS
Official Title
Improvement of Memory in Mild Cognitive Impairment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 55 years or older
- Clinical diagnosis of mild cognitive impairment (MCI) confirmed by comprehensive assessment and neuropsychological tests
- Diagnosis confirmed by study physician based on cognitive evaluation and history
- Able to understand and provide informed consent
- Willing and able to comply with all study procedures
- Signed informed consent form
- Women of childbearing potential must perform a pregnancy test during screening
- Caregiver is at least 21 years old
- Caregiver reports proficiency with computer or tablet use
- Caregiver willing to learn how to use tACS and available to administer it throughout the study
- Caregiver signed informed consent form
- Women of childbearing potential among caregivers must perform a pregnancy test during screening
You will not qualify if you...
- Age under 55 years
- Current diagnosis of psychiatric disorders such as schizophrenia, bipolar disorder, or depression
- History of other progressive or genetic neurological disorders (e.g., Parkinson's disease, multiple sclerosis, tubular sclerosis) or acquired neurological diseases (e.g., stroke, brain injury, tumor)
- History of head trauma with prolonged loss of consciousness
- Current poorly controlled headaches or chronic migraine medication use
- History of fainting spells possibly related to seizures
- History of seizures or epilepsy diagnosis
- Unstable or uncontrolled medical conditions that could cause emergencies during seizures (e.g., heart malformations, cardiac dysrhythmia, asthma)
- Contraindications for MRI or tACS
- Presence of metal in brain or skull (except dental fillings) unless cleared by a doctor
- Skin conditions like dermatitis, psoriasis, or eczema
- Implanted electrically, magnetically, or mechanically activated devices (e.g., pacemaker, implanted defibrillator, nerve stimulator)
- Serious life-threatening diseases such as congestive heart failure, chronic obstructive pulmonary disease, or active cancer
- Pregnancy
- Adults who lack capacity to consent
- Caregivers with insufficient understanding of study procedures
- Caregivers with poor eyesight, severe arthritis, pain, deformity, or other conditions interfering with tACS administration
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Geneva, Campus Biotech
Geneva, Switzerland, 1202
Actively Recruiting
Research Team
L
Lucie Bréchet, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here