Actively Recruiting
Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)
Led by University of Miami · Updated on 2026-03-02
90
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
Sponsors
U
University of Miami
Lead Sponsor
C
Congressionally Directed Medical Research Programs
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a study of infertility which often occurs in men with spinal cord injury. Most men with spinal cord injury have a normal sperm count but abnormally low sperm motility - which means that the sperm does not swim well. This study will determine if a medicine given by mouth will improve sperm motility in men with spinal cord injuries. The medicine is called probenecid.
CONDITIONS
Official Title
Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subject has a traumatic spinal cord injury.
- Subject is male and is 18 years or older.
You will not qualify if you...
- Subject has been injured less than 1 year.
- The subject is known to be azoospermic.
- The subject has an indwelling urethral Foley catheter.
- Subject is under the age of 18 years.
- Subject has an unstable medical condition including Crohn's disease, ulcerative colitis, colon cancer, or other conditions deemed exclusionary.
- Subject is unable to consent or understand the study procedures.
- Subject has a permanent implanted electrical device like a pacemaker or spinal cord stimulator.
- Procedure or medication is contraindicated for the subject.
- Subject has hypersensitivity to probenecid.
- Subject has a history of uric acid kidney stones or peptic ulcer.
- Subject had a febrile urinary tract infection within 2 months before enrollment.
- Subject is taking methotrexate, aspirin, other salicylates, or anti-inflammatory medicines.
- Subject has a history of Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
Research Team
O
Odaro Ugbo, BSc
CONTACT
O
Orrey Padilla
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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